Staurosporine Inhibits Frequency-Dependent Myofilament Desensitization in Intact Rabbit Cardiac Trabeculae
Figure 2
Average twitch and calcium transient data from trabeculae treated with staurosporine or vehicle (DMSO) ( for each group). Panels (a) and (b) show the developed force (a) and relaxation time to 90% of peak (RT50) at each frequency 1 through 4 Hz. Analysis by two-way ANOVA (Bonferroni correction, ) showed that frequency significantly altered force and relaxation, but staurosporine did not significantly alter the FFR or FDAR. Panels (c) and (d) show the average systolic calcium levels (c) and time constant of calcium decline (tau). There was no significant effect of 100 nM staurosporine, nor an interaction between staurosporine and frequency. The effect of frequency within each group was analyzed by one-way AVOVA (*significantly different from 1 Hz).
