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Biochemistry Research International
Volume 2012, Article ID 480529, 7 pages
Research Article

Increased Urine IgM and IgG2 Levels, Indicating Decreased Glomerular Size Selectivity, Are Not Affected by Dalteparin Therapy in Patients with Type 2 Diabetes

1Department of Nephrology, Institution of Clinical Sciences, Lund University Hospital, 22185 Lund, Sweden
2Primary Care Unit, Capio-Citykliniken, Björkhemsvägen 15C, 29154 Kristianstad, Sweden
3Department of Cardiology, Danderyd Hospital, 18288 Stockholm, Sweden
4Department of Endocrinology, Malmö University Hospital, 20502 Malmö, Sweden
5Diabetes Centrum, Sahlgrenska University Hospital, 41345 Göteborg, Sweden
6Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, 41345 Göteborg, Sweden
7Department of Endocrinology, Karolinska University Hospital, 17164 Solna, Sweden
8Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, 18288 Stockholm, Sweden

Received 29 August 2011; Revised 8 November 2011; Accepted 22 November 2011

Academic Editor: Barbara Bartolini

Copyright © 2012 Ole Torffvit et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Fifty-four type 2 diabetic patients with neuroischemic foot ulcers were randomised to treatment with 5000 IU of dalteparin, ( ), or physiological saline, ( ), once daily until ulcer healing or for a maximum of 6 months. Thirty-three patients had normo-, 15 micro-, and 6 macroalbuminuria. The urinary levels of IgM and IgG2 were elevated in 47 and 50 patients, respectively. Elevated urinary levels of IgM and IgG2 indicate decreased glomerular size selectivity. Urine IgM levels were associated with IGF-1/IGFBP-1 and IGFBP-1 levels. Dalteparin treatment increased urinary levels of glycosaminoglycans ( ) and serum IGFBP-1 ( ) while no significant effects were seen in any of the other studied parameters. In conclusion, dalteparin therapy in patients with type 2 diabetes had no effects on urinary levels of albumin, IgM, or IgG2 despite significantly increased glycosaminoglycans in urine. Elevated urinary levels of IgM and IgG2 might be more sensitive markers of renal disease than albuminuria in patients with type 2 diabetes and antihypertensive therapy.