Strategies to Identify Recognition Signals and Targets of SUMOylation

Figure 6

Integrated view of the role of SUMO in the p53 Signalling pathway. Ingenuity analysis of proteins that have been identified (in gray) in recent studies: TP53, WT1, PRKDC, TP63, PIK3C2A, TP73, HDAC1, MDM2, BAX, EP300, RB1, PCNA, MDM4, JUN, GSK3B, HIPK2, PML, BRCA1, CDK2, and SIRT1 (Figure 4 and Supplementary Table  1) by mass spectrometry using His-6-SUMO-tagged.