Role of in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells
Figure 3
Phase-contrast photomicrographs showing SIPS in breast cancer cell lines that express mutant p53. Cells were exposed to 60Co γ-radiation (8 Gy) or sham-irradiated (0 Gy), incubated for seven days, and evaluated for features of SIPS (flattened and enlarged cellular morphology and positive (blue) staining in the senescence-associated β-galactosidase assay).
