A Quantitative Structure-Activity Relationship and Molecular Modeling Study on a Series of Heteroaryl- and Heterocyclyl-Substituted Imidazo[1,2-a]Pyridine Derivatives Acting as Acid Pump Antagonists

Table 4

Data related to Lipinski rules in comparison to those licensed.

Predicted compound; (Table 2)	Lipinski parameters
	MW	HA	HD	log P
1	504.622	6	3	4.65
2	499.644	6	4	4.43
3	479.611	7	5	2.09
4	506.594	7	4	3.34
5	501.616	7	5	2.52
6	499.600	7	5	2.32
7	497.584	7	5	2.10
8	489.562	7	5	1.48
9	453.573	7	5	1.67
10	487.590	7	5	2.07
11	503.589	8	5	1.55
12	489.629	6	4	3.64
13	465.584	7	5	1.65
14	453.573	7	5	1.83
15	489.562	8	4	2.36
16	457.564	8	4	3.28
17	479.569	6	4	4.60
Rabeprazole	339.388	5	1	2.56
Lansoprazole	369.361	7	1	3.03
Omeprazole	383.370	8	1	2.18
Pantoprazole	345.416	5	1	2.43