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Biochemistry Research International
Volume 2014, Article ID 703128, 5 pages
Research Article

Roles of the Oxidative Stress and ADMA in the Development of Deep Venous Thrombosis

1School of Health, Bozok University, 66200 Yozgat, Turkey
2Department of Biochemistry, Yuzuncu Yil University Medical Faculty, 65080Van, Turkey
3Department of Medical Biology, Yuzuncu Yil University Medical Faculty, 65080 Van, Turkey
4Department of Cardiovascular Surgery, Bozok University Medical Faculty, 66200 Yozgat, Turkey

Received 23 December 2013; Revised 13 March 2014; Accepted 13 March 2014; Published 13 April 2014

Academic Editor: Tzi Bun Ng

Copyright © 2014 Meral Ekim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Venous thromboembolism has multifactorial origin and occurs in the context of complex interactions between environmental and genetic predisposing factors. Oxidative stress plays an important role in the physiopathology of venous thrombosis. Current study examined the role of oxidative stress and asymmetric dimethylarginine in the development of DVT with the parameters such as serum malondialdehyde (MDA), glutathione peroxidase (GSH-Px), catalase, ADMA, homocysteine, folic acid, vitamin B6, and vitamin B12 levels. Serum MDA levels were found significantly ( ) high in patients with DVT compared with control group. Additionally, serum B6 levels were found significantly ( ) low in patients with DVT compared with healthy volunteers. There were no significant differences between the groups in terms of the other parameters ( ). This study showed that patients with DVT have increased oxidative stress compared with the healthy volunteers whereas there was no significant difference between the groups in terms of serum ADMA levels. Thus serum ADMA levels seemed to be not related with development of DVT.