Research Article

Transcriptional Activation of p53 during Cold Induced Torpor in the 13-Lined Ground Squirrel Ictidomys tridecemlineatus

Table 1

Unique substitutions found in the ground squirrel p53 protein sequence at amino acid residues that are conserved in nonhibernating mammals. Bracket indicates amino acid position in human.

Conserved amino acidSquirrel specific amino acidAmino acid positionProperty substitution

LysAsn24Charged neutral
ProSer78 (80)Nonpolar polar
ProLeu80 (82)Conserved
LysAsn99 (101)Charged neutral
LeuIle112 (114)Conserved
AspGlu226 (228)Conserved
LysArg290 (292)Conserved
LeuPro299 (302)Conserved
GluAla334 (336)Charged, polar neutral, nonpolar (hydrophobic)
AlaPro362 (364)Conserved
SerPro364 (366)Polar nonpolar
MetIle382 (384)Conserved