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Biochemistry Research International
Volume 2016 (2016), Article ID 3130469, 12 pages
http://dx.doi.org/10.1155/2016/3130469
Review Article

Biosensors in Health Care: The Milestones Achieved in Their Development towards Lab-on-Chip-Analysis

Department of Biochemistry, All India Institute of Medical Sciences, Raipur, Chhattisgarh 492099, India

Received 15 October 2015; Revised 4 January 2016; Accepted 19 January 2016

Academic Editor: Gary A. Lorigan

Copyright © 2016 Suprava Patel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Nurunnabi, K. J. Cho, J. S. Choi, K. M. Huh, and Y.-K. Lee, “Targeted near-IR QDs-loaded micelles for cancer therapy and imaging,” Biomaterials, vol. 31, no. 20, pp. 5436–5444, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Malima, S. Siavoshi, T. Musacchio et al., “Highly sensitive microscale in vivo sensor enabled by electrophoretic assembly of nanoparticles for multiple biomarker detection,” Lab on a Chip, vol. 12, no. 22, pp. 4748–4754, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. B. N. G. Giepmans, S. R. Adams, M. H. Ellisman, and R. Y. Tsien, “The fluorescent toolbox for assessing protein location and function,” Science, vol. 312, no. 5771, pp. 217–224, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Hasan, A. Memic, N. Annabi et al., “Electrospun scaffolds for tissue engineering of vascular grafts,” Acta Biomaterialia, vol. 10, no. 1, pp. 11–25, 2014. View at Publisher · View at Google Scholar
  5. A. Hasan, K. Ragaert, W. Swieszkowski et al., “Biomechanical properties of native and tissue engineered heart valve constructs,” Journal of Biomechanics, vol. 47, no. 9, pp. 1949–1963, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Karlsson and A. Fält, “Experimental design for kinetic analysis of protein-protein interactions with surface plasmon resonance biosensors,” Journal of Immunological Methods, vol. 200, no. 1-2, pp. 121–133, 1997. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. Cui, Q. Wei, H. Park, and C. M. Lieber, “Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species,” Science, vol. 293, no. 5533, pp. 1289–1292, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. J. R. Heath, “Label-free nanowire and nanotube biomolecular sensors for in-vitro diagnosis of cancer and other diseases,” in Nanobiotechnology II: More Concepts and Applications, chapter 12, John Wiley & Sons, Hoboken, NJ, USA, 2007. View at Publisher · View at Google Scholar
  9. H. P. Lang, M. Hegner, and C. Gerber, “Cantilever array sensors for bioanalysis and diagnostics,” in Nanobiotechnology II: More Concepts and Applications, C. A. Mirkin and C. M. Niemeyer, Eds., chapter 10, pp. 175–195, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2007. View at Publisher · View at Google Scholar
  10. K. Boeneman, J. B. Delehanty, K. Susumu, M. H. Stewart, J. R. Deschamps, and I. L. Medintz, “Quantum dots and fluorescent protein FRET-based biosensors,” Advances in Experimental Medicine and Biology, vol. 733, pp. 63–74, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. R. K. Darsanaki, A. Azizzadeh, M. Nourbakhsh, G. Raeisi, and M. A. Aliabadi, “Biosensors: functions and applications,” Journal of Biology and Today's World, vol. 2, no. 1, pp. 53–61, 2013. View at Publisher · View at Google Scholar
  12. D. Grieshaber, “English: biosensor system and components,” Source, 2008, https://commons.wikimedia.org/wiki/File:Biosensor_System.jpg. View at Google Scholar
  13. D. Dey and T. Goswami, “Optical biosensors: a revolution towards quantum nanoscale electronics device fabrication,” Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 348218, 7 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Pineda, Z. J. Han, and K. Ostrikov, “Plasma-enabled carbon nanostructures for early diagnosis of neurodegenerative diseases,” Materials, vol. 7, no. 7, pp. 4896–4929, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Hasan, M. Nurunnabi, M. Morshed et al., “Recent advances in application of biosensors in tissue engineering,” BioMed Research International, vol. 2014, Article ID 307519, 18 pages, 2014. View at Publisher · View at Google Scholar
  16. S. Laschi, M. Fránek, and M. Mascini, “Screen-printed electrochemical immunosensors for PCB detection,” Electroanalysis, vol. 12, no. 16, pp. 1293–1298, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. P. D'Orazio, “Biosensors in clinical chemistry,” Clinica Chimica Acta, vol. 334, no. 1-2, pp. 41–69, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. C. B. Jacobs, M. J. Peairs, and B. J. Venton, “Review: carbon nanotube based electrochemical sensors for biomolecules,” Analytica Chimica Acta, vol. 662, no. 2, pp. 105–127, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Shao, J. Wang, H. Wu, J. Liu, I. A. Aksay, and Y. Lin, “Graphene based electrochemical sensors and biosensors: a review,” Electroanalysis, vol. 22, no. 10, pp. 1027–1036, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Liu, Z. Matharu, M. C. Howland, A. Revzin, and A. L. Simonian, “Affinity and enzyme-based biosensors: recent advances and emerging applications in cell analysis and point-of-care testing,” Analytical and Bioanalytical Chemistry, vol. 404, no. 4, pp. 1181–1196, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. M. R. Nejadnik, F. L. Deepak, and C. D. Garcia, “Adsorption of glucose oxidase to 3-D scaffolds of carbon nanotubes: analytical applications,” Electroanalysis, vol. 23, no. 6, pp. 1462–1469, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. V. A. Pedrosa, S. Paliwal, S. Balasubramanian et al., “Enhanced stability of enzyme organophosphate hydrolase interfaced on the carbon nanotubes,” Colloids and Surfaces B: Biointerfaces, vol. 77, no. 1, pp. 69–74, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Liu, D. Yu, C. Zeng, Z. Miao, and L. Dai, “Biocompatible graphene oxide-based glucose biosensors,” Langmuir, vol. 26, no. 9, pp. 6158–6160, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. X. Kang, J. Wang, H. Wu, I. A. Aksay, J. Liu, and Y. Lin, “Glucose oxidase-graphene-chitosan modified electrode for direct electrochemistry and glucose sensing,” Biosensors and Bioelectronics, vol. 25, no. 4, pp. 901–905, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Ramanathan, H. R. Luckarift, A. Sarsenova et al., “Lysozyme-mediated formation of protein-silica nano-composites for biosensing applications,” Colloids and Surfaces B: Biointerfaces, vol. 73, no. 1, pp. 58–64, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Jia, B. Wang, A. Wu, G. Cheng, Z. Li, and S. Dong, “A method to construct a third-generation horseradish peroxidase biosensor: self-assembling gold nanoparticles to three-dimensional sol-gel network,” Analytical Chemistry, vol. 74, no. 9, pp. 2217–2223, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. V. A. Pedrosa, J. Yan, A. L. Simonian, and A. Revzin, “Micropatterned nanocomposite hydrogels for biosensing applications,” Electroanalysis, vol. 23, no. 5, pp. 1142–1149, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Xiao, F. Patolsky, E. Katz, J. F. Hainfeld, and I. Willner, “‘Plugging into enzymes’: nanowiring of redox enzymes by a gold nanoparticle,” Science, vol. 299, no. 5614, pp. 1877–1881, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. B. Strehlitz, “Methods in biotechnology, vol. 6. Enzyme and microbial biosensors. Techniques and protocols. Totowa, New Jersey: Humana Press, 1998 264 pages, $69.50 ISBN 0-896-03410-0,” Acta Biotechnologica, vol. 19, no. 1, p. 26, 1999. View at Publisher · View at Google Scholar
  30. S. Dolatabadi and D. Manjulakumari, “Microbial biosensors and bioelectronics,” Research Journal of Biotechnology, vol. 7, no. 3, pp. 102–108, 2012, https://www.researchgate.net/publication/230739386_Microbial_Biosensors_and_Bioelectronics. View at Google Scholar
  31. Z. Chen, M. Lu, D. Zou, and H. Wang, “An E. coli SOS-EGFP biosensor for fast and sensitive detection of DNA damaging agents,” Journal of Environmental Sciences, vol. 24, no. 3, pp. 541–549, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Rizzuto, P. Pinton, M. Brini, A. Chiesa, L. Filippin, and T. Pozzan, “Mitochondria as biosensors of calcium microdomains,” Cell Calcium, vol. 26, no. 5, pp. 193–199, 1999. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Campàs, R. Carpentier, and R. Rouillon, “Plant tissue-and photosynthesis-based biosensors,” Biotechnology Advances, vol. 26, no. 4, pp. 370–378, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Kiilerich-Pedersen and N. Rozlosnik, “Cell-based biosensors: electrical sensing in microfluidic devices,” Diagnostics, vol. 2, no. 4, pp. 83–96, 2012. View at Publisher · View at Google Scholar
  35. D. Kwasny, K. Kiilerich-Pedersen, J. Moresco, M. Dimaki, N. Rozlosnik, and W. E. Svendsen, “Microfluidic device to study cell transmigration under physiological shear stress conditions,” Biomedical Microdevices, vol. 13, no. 5, pp. 899–907, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. S. K. Arya, K. C. Lee, D. Bin Dah'alan, Daniel, and A. R. A. Rahman, “Breast tumor cell detection at single cell resolution using an electrochemical impedance technique,” Lab on a Chip, vol. 12, no. 13, pp. 2362–2368, 2012. View at Publisher · View at Google Scholar
  37. R. Huang, Y. Lin, Q. Shi et al., “Enhanced protein profiling arrays with ELISA-based amplification for high-throughput molecular changes of tumor patients' plasma,” Clinical Cancer Research, vol. 10, no. 2, pp. 598–609, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. E. Paleček, “Past, present and future of nucleic acids electrochemistry,” Talanta, vol. 56, no. 5, pp. 809–819, 2002. View at Publisher · View at Google Scholar · View at Scopus
  39. U. Bora, A. Sett, and D. Singh, “Nucleic acid based biosensors for clinical applications,” Biosensors Journal, vol. 1, p. 104, 2013. View at Google Scholar
  40. C.-Y. Hong, X. Chen, T. Liu et al., “Ultrasensitive electrochemical detection of cancer-associated circulating microRNA in serum samples based on DNA concatamers,” Biosensors and Bioelectronics, vol. 50, pp. 132–136, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Mascini and S. Tombelli, “Biosensors for biomarkers in medical diagnostics,” Biomarkers, vol. 13, no. 7-8, pp. 637–657, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. J. R. Cole, L. W. Dick Jr., E. J. Morgan, and L. B. McGown, “Affinity capture and detection of immunoglobulin E in human serum using an aptamer-modified surface in matrix-assisted laser desorption/ionization mass spectrometry,” Analytical Chemistry, vol. 79, no. 1, pp. 273–279, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. C.-W. Yen, H. de Puig, J. O. Tam et al., “Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses,” Lab on a Chip, vol. 15, no. 7, pp. 1638–1641, 2015. View at Publisher · View at Google Scholar
  44. D. Duan, K. Fan, D. Zhang et al., “Nanozyme-strip for rapid local diagnosis of Ebola,” Biosensors and Bioelectronics, vol. 74, pp. 134–141, 2015. View at Publisher · View at Google Scholar
  45. U.-C. Schröder, F. Bokeloh, M. O'Sullivan et al., “Rapid, culture-independent, optical diagnostics of centrifugally captured bacteria from urine samples,” Biomicrofluidics, vol. 9, no. 4, Article ID 044118, 2015. View at Publisher · View at Google Scholar
  46. M. A. Pfaller, D. M. Wolk, and T. J. Lowery, “T2MR and T2Candida: novel technology for the rapid diagnosis of candidemia and invasive candidiasis,” Future Microbiology, vol. 11, no. 1, pp. 103–117, 2016. View at Publisher · View at Google Scholar
  47. A. F. Sarioglu, N. Aceto, N. Kojic et al., “A microfluidic device for label-free, physical capture of circulating tumor cell clusters,” Nature Methods, vol. 12, no. 7, pp. 685–691, 2015. View at Publisher · View at Google Scholar
  48. J. D. Besant, E. H. Sargent, and S. O. Kelley, “Rapid electrochemical phenotypic profiling of antibiotic-resistant bacteria,” Lab on a Chip, vol. 15, no. 13, pp. 2799–2807, 2015. View at Publisher · View at Google Scholar
  49. M. D. Perkins and M. Kessel, “What Ebola tells us about outbreak diagnostic readiness,” Nature Biotechnology, vol. 33, no. 5, pp. 464–469, 2015. View at Publisher · View at Google Scholar
  50. R. Barson, “Non-invasive device could end daily finger pricking for people with diabetes,” January 2016, http://www.leeds.ac.uk/news/article/3723/non-invasive_device_could_end_daily_finger_pricking_for_people_with_diabetes.
  51. T. R. Shojaei, M. A. Mohd Salleh, M. Tabatabaei et al., “Development of sandwich-form biosensor to detect Mycobacterium tuberculosis complex in clinical sputum specimens,” The Brazilian Journal of Infectious Diseases, vol. 18, no. 6, pp. 600–608, 2014. View at Publisher · View at Google Scholar
  52. C. Sengiz, G. Congur, and A. Erdem, “Development of ionic liquid modified disposable graphite electrodes for label-free electrochemical detection of DNA hybridization related to Microcystis spp.,” Sensors, vol. 15, no. 9, pp. 22737–22749, 2015. View at Publisher · View at Google Scholar
  53. Y. Zhu, P. Chandra, and Y.-B. Shim, “Ultrasensitive and selective electrochemical diagnosis of breast cancer based on a hydrazine-Au nanoparticle-aptamer bioconjugate,” Analytical Chemistry, vol. 85, no. 2, pp. 1058–1064, 2013. View at Publisher · View at Google Scholar · View at Scopus
  54. P.-H. Huang, L. Ren, N. Nama et al., “An acoustofluidic sputum liquefier,” Lab on a Chip, vol. 15, no. 15, pp. 3125–3131, 2015. View at Publisher · View at Google Scholar
  55. A. Courbet, D. Endy, E. Renard, F. Molina, and J. Bonnet, “Detection of pathological biomarkers in human clinical samples via amplifying genetic switches and logic gates,” Science Translational Medicine, vol. 7, no. 289, Article ID 289ra83, 2015. View at Publisher · View at Google Scholar
  56. K. E. Mach, R. Mohan, S. Patel, P. K. Wong, M. Hsieh, and J. C. Liao, “Development of a biosensor-based rapid urine test for detection of urogenital schistosomiasis,” PLoS Neglected Tropical Diseases, vol. 9, no. 7, Article ID e0003845, 2015. View at Publisher · View at Google Scholar
  57. H. Im, C. M. Castro, H. Shao et al., “Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone,” Proceedings of the National Academy of Sciences, vol. 112, no. 18, pp. 5613–5618, 2015. View at Google Scholar
  58. T. Zheng, N. Pierre-Pierre, X. Yan et al., “Gold nanoparticle-enabled blood test for early stage cancer detection and risk assessment,” ACS Applied Materials & Interfaces, vol. 7, no. 12, pp. 6819–6827, 2015. View at Publisher · View at Google Scholar
  59. A. Tashtoush, “Multi-labs-on-a chip based optical detection for atto-molar cancer markers concentration,” in Proceedings of the 5th National Symposium on Information Technology: Towards New Smart World (NSITNSW '15), pp. 1–7, Riyadh, Saudi Arabia, Feburary 2015. View at Publisher · View at Google Scholar
  60. Y. Jain, C. Rana, A. Goyal, N. Sharma, M. L. Verma, and A. K. Jana, “Biosensors, types and applications,” in Proceedings of the International Conference on Biomedical Engineering and Assistive Technologies (BEATS '10), pp. 1–6, Jalandhar, India, January 2010.
  61. C. Gouvea, “Biosensors for health applications,” July 2011, http://www.intechopen.com/books/biosensors-for-health-environment-and-biosecurity/biosensors-for-health-applications.
  62. M. L. Sin, K. E. Mach, P. K. Wong, and J. C. Liao, “Advances and challenges in biosensor-based diagnosis of infectious diseases,” Expert Review of Molecular Diagnostics, vol. 14, no. 2, pp. 225–244, 2014. View at Publisher · View at Google Scholar · View at Scopus
  63. C. D. Chin, V. Linder, and S. K. Sia, “Commercialization of microfluidic point-of-care diagnostic devices,” Lab on a Chip, vol. 12, no. 12, pp. 2118–2134, 2012. View at Publisher · View at Google Scholar · View at Scopus
  64. E. Paleček, J. Tkáč, M. Bartošík, T. Bertók, V. Ostatná, and J. Paleček, “Electrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomics,” Chemical Reviews, vol. 115, no. 5, pp. 2045–2108, 2015. View at Publisher · View at Google Scholar
  65. H. T. Ngo, H.-N. Wang, A. M. Fales, and T. Vo-Dinh, “Label-free DNA biosensor based on SERS molecular sentinel on nanowave chip,” Analytical Chemistry, vol. 85, no. 13, pp. 6378–6383, 2013. View at Publisher · View at Google Scholar · View at Scopus
  66. L. Breydo, J. W. Wu, and V. N. Uversky, “α-Synuclein misfolding and Parkinson's disease,” Biochimica et Biophysica Acta (BBA)—Molecular Basis of Disease, vol. 1822, no. 2, pp. 261–285, 2012. View at Publisher · View at Google Scholar · View at Scopus
  67. A. Veloso and K. Kerman, “Advances in electrochemical detection for study of neurodegenerative disorders,” Analytical and Bioanalytical Chemistry, vol. 405, no. 17, pp. 5725–5741, 2013. View at Publisher · View at Google Scholar · View at Scopus
  68. E. Paleček, V. Ostatná, H. Černocká, A. C. Joerger, and A. R. Fersht, “Electrocatalytic monitoring of metal binding and mutation-induced conformational changes in p53 at picomole level,” Journal of the American Chemical Society, vol. 133, no. 18, pp. 7190–7196, 2011. View at Publisher · View at Google Scholar · View at Scopus
  69. M. Zatloukalová, E. Orolinová, M. Kubala, J. Hrbáč, and J. Vacek, “Electrochemical determination of transmembrane protein Na+/K+-ATPase and its cytoplasmic loop C45,” Electroanalysis, vol. 24, no. 8, pp. 1758–1765, 2012. View at Publisher · View at Google Scholar
  70. H. J. Watts, C. R. Lowe, and D. V. Pollard-Knight, “Optical biosensor for monitoring microbial cells,” Analytical Chemistry, vol. 66, no. 15, pp. 2465–2468, 1994. View at Publisher · View at Google Scholar · View at Scopus
  71. R. Syam, K. Davis, M. Pratheesh, R. Anoopraj, and B. Joseph, “Biosensors: a novel approach for pathogen detection,” VetScan, vol. 7, no. 1, pp. 14–18, 2012. View at Google Scholar
  72. M. F. Frasco and N. Chaniotakis, “Semiconductor quantum dots in chemical sensors and biosensors,” Sensors, vol. 9, no. 9, pp. 7266–7286, 2009. View at Publisher · View at Google Scholar · View at Scopus
  73. Y. Wang, R. Hu, G. Lin, I. Roy, and K.-T. Yong, “Functionalized quantum dots for biosensing and bioimaging and concerns on toxicity,” ACS Applied Materials & Interfaces, vol. 5, no. 8, pp. 2786–2799, 2013. View at Publisher · View at Google Scholar · View at Scopus
  74. T. Kuila, S. Bose, P. Khanra, A. K. Mishra, N. H. Kim, and J. H. Lee, “Recent advances in graphene-based biosensors,” Biosensors and Bioelectronics, vol. 26, no. 12, pp. 4637–4648, 2011. View at Publisher · View at Google Scholar · View at Scopus
  75. C. Ruan, W. Shi, H. Jiang et al., “One-pot preparation of glucose biosensor based on polydopamine-graphene composite film modified enzyme electrode,” Sensors and Actuators B: Chemical, vol. 177, pp. 826–832, 2013. View at Publisher · View at Google Scholar · View at Scopus
  76. H. Sun, L. Wu, W. Wei, and X. Qu, “Recent advances in graphene quantum dots for sensing,” Materials Today, vol. 16, no. 11, pp. 433–442, 2013. View at Publisher · View at Google Scholar · View at Scopus
  77. J. Peng, W. Gao, B. K. Gupta et al., “Graphene quantum dots derived from carbon fibers,” Nano Letters, vol. 12, no. 2, pp. 844–849, 2012. View at Publisher · View at Google Scholar · View at Scopus
  78. M. Ra, A. Gade, S. Gaikwad, P. D. Marcato, and N. Durán, “Biomedical applications of nanobiosensors: the state-of-the-art,” Journal of the Brazilian Chemical Society, vol. 23, no. 1, pp. 14–24, 2012. View at Google Scholar · View at Scopus
  79. P. Chandra, “Electrochemical nanobiosensors for cancer diagnosis,” Journal of Analytical & Bioanalytical Techniques, vol. 6, no. 2, article e119, 2015. View at Publisher · View at Google Scholar
  80. H. Chen and R. E. Nordon, “Application of microfluidics to study stem cell dynamics,” in Emerging Trends in Cell and Gene Therapy, chapter 19, pp. 435–470, Springer, New York, NY, USA, 2013, http://espace.library.uq.edu.au/view/UQ:309652. View at Publisher · View at Google Scholar
  81. S. Kumar, S. Kumar, M. A. Ali et al., “Microfluidic-integrated biosensors: prospects for point-of-care diagnostics,” Biotechnology Journal, vol. 8, no. 11, pp. 1267–1279, 2013. View at Publisher · View at Google Scholar · View at Scopus
  82. C. Zhao, M. M. Thuo, and X. Liu, “Corrigendum: a microfluidic paper-based electrochemical biosensor array for multiplexed detection of metabolic biomarkers (2013 Sci. Technol. Adv. Mater. 14 054402),” Science and Technology of Advanced Materials, vol. 16, no. 4, 2015, https://www.researchgate.net/publication/281488411_Corrigendum_A_microfluidic_paper-based_electrochemical_biosensor_array_for_multiplexed_detection_of_metabolic_biomarkers_2013_Sci_Technol_Adv_Mater_14_054402. View at Google Scholar