Table 2: IC50 values of compounds 1a, 1b, and 1c on cancer cell lines.

Cancer cell linesIC50 (μmol/L)
1a1b1cAdriamycin

PC3131.26 ± 15.3659.78 ± 12.1367.24 ± 13.148.06 ± 1.42
BPH1214.61 ± 14.2590.03 ± 11.3667.39 ± 15.8911.36 ± 1.14
K56252.22 ± 10.3911.95 ± 2.364.56 ± 0.88
HEL9.72 ± 2.563.12 ± 0.32

Cell lines include the following: human prostate cancer cell line (PC3), human prostate mesenchymal cell line (BPH1), and human leukemia cell lines (K562 and HEL). Cell viability (%) was determined by MTT assay to calculate the IC50. All the assayed compounds were dissolved in DMSO, with a final concentration of DMSO was less than 0.1%. Control cells were treated only with the medium containing 0.1% DMSO. Values were mean ± standard deviation of three independent experiments.