Biochemistry Research International

Research Article

The Protective Effect of Naringenin-Oxime on Cisplatin-Induced Toxicity in Rats

Table 2

Effects of cisplatin (7 mg/kg), naringenin oxime (20 mg/kg), Cis + NOX₂₀, and Cis + NOX₄₀ on TOS, TAS, and OSI in serum, kidney, and liver of rats.


	TOS			TAS			OSI
	Serum	Kidney	Liver	Serum	Kidney	Liver	Serum	Kidney	Liver

Control	10,5 ± 1,	8,3 ± 1,	7,38 ± 1,2	1,28 ± 0,2	0,87 ± 0,0	0,72 ± 0,0	0,88 ± 0,1	0,96 ± 0,0	1,03 ± 0,1
Cis	18,1 ± 1,	13,4 ± 1,	11,72 ± 1,4	0,68 ± 0,	0,61 ± 0,1	0,43 ± 0,0	2,71 ± 0,8	2,33 ± 0,5	2,78 ± 0,5
Cis + NOX₂₀	15,3 ± 2,	11,4 ± 2,1	9,51 ± 1,17	0,97 ± 0,16	0,76 ± 0,09	0,66 ± 0,16	1,64 ± 0,5	1,51 ± 0,2	1,53 ± 0,4
Cis + NOX₄₀	16,9 ± 3,	10,1 ± 1,	8,51 ± 1,1	1,13 ± 0,3	0,89 ± 0,0	0,81 ± 0,1	1,54 ± 0,2	1,14 ± 0,2	1,06 ± 0,1
NOX₂₀	9,8 ± 2,	8,3 ± 1,	7,42 ± 1,4	1,20 ± 0,1	0,88 ± 0,	0,79 ± 0,1	0,82 ± 0,	0,26 ± 0,2	0,98 ± 0,2
value	0,000	0,000	0,000	0,000	0,000	0,000	0,000	0,000	0,000

Values are given as the means ± SD. There were no significant differences between the cis and control groups in terms of any parameter (). , compared with the control group. , groups in which Cis and NOX are treated together compared with the Cis group.