Biochemistry Research International

Research Article

The Protective Effect of Naringenin-Oxime on Cisplatin-Induced Toxicity in Rats

Table 4

Effect of naringenin oxime (NOX) on serum liver enzymes, renal function markers, myeloperoxidase (MPO), and ceruloplasmin (CERP) of cisplatin induced rat.


	BUN (mg/dl)	Cre (mg/dl)	ALT (U/L)	AST (U/L)	MPO (U/g)	CERP

Control	38,69 ± 6,	0,28 ± 0,0	35,4 ± 6,	73,3 ± 4,1	27,2 ± 1,6	599,9 ± 41,1
Cis	64,11 ± 5,	0,60 ± 0,0	67,3 ± 8,	144,2 ± 9,1	30 ± 2,8	666,9 ± 86,6
Cis + NOX₂₀	55,67 ± 5,	0,46 ± 0,0	52,6 ± 9,	105,3 ± 18,	28,8 ± 2,8	601,6 ± 95,4
Cis + NOX₄₀	47,30 ± 4,	0,38 ± 0,0	42,9 ± 8,	86,7 ± 12,	28 ± 5,6	624,0 ± 30,7
NOX₂₀	37,81 ± 6,	0,30 ± 0,0	37,2 ± 6,	73,5 ± 10,	24,4 ± 4	597,4 ± 183,0
value	0,000	0,000	0,000	0,000	0,600	0,685

Values are given as the means ± SD. There were no significant differences between the cis and control groups in terms of any parameter (). , compared with the control group. , groups in which Cis and NOX are treated together compared with the Cis group.