Cryptolepine, the Main Alkaloid of the Antimalarial <i>Cryptolepis sanguinolenta</i> (Lindl.) Schlechter, Induces Malformations in Zebrafish Embryos

<div>(a) Representative micrographs of overt toxicity seen in zebrafish embryos exposed to solvent control, cryptolepine 5 × 10<sup>2</sup> <i>μ</i>M, and 3 × 10<sup>−2</sup> <i>μ</i>M mercury chloride. The micrographs were taken at 72 hpf (×4). (b) Morphology of eleutheroembryos treated with cryptolepine and mercury chloride compared to the solvent control at postfertilization day 5. A = pericardial area; B = heart wall; C = somites; D = eye; E = yolk extension. (c) Photomicrograph of the pericardial area of zebrafish eleutheroembryos treated with cryptolepine and mercury chloride compared to the solvent control at postfertilization day 5.</div>

Biochemistry Research International

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Figure 5

Figure 5: Cryptolepine, the Main Alkaloid of the Antimalarial <i>Cryptolepis sanguinolenta</i> (Lindl.) Schlechter, Induces Malformations in Zebrafish Embryos 

Figure 5 | Cryptolepine, the Main Alkaloid of the Antimalarial Cryptolepis sanguinolenta (Lindl.) Schlechter, Induces Malformations in Zebrafish Embryos 