Research Article
Synthesis of Surfactants Derived from 2-Mercaptobenzimidazole and Study of Their Acute Toxicity and Analgesic and Psychotropic Activities
Table 4
Results of the sedative activity of the products 2 and 3 at the doses of 200 and 400 mg/kg.
| | | Witness | Bromazepam | 2 (200 mg/kg) | 2 (400 mg/kg) | 3 (200 mg/kg) | 3 (400 mg/kg) |
| | Traction test | Percentage of falls (%) | 0 | 100 | 0 | 0 | 0 | 0 | | Average fall time (s) | 0 | 10.0 ± 0.9 | 0 | 0 | 0 | 0 | | Average recovery time (s) | 0.5 ± 0.1 | 0 | 1.32 ± 0.49 | 2.36 ± 0.91 | 1.14 ± 0.17 | 1.56 ± 0.60 | | Chemney test | Average time to climb the chemney (s) | 3.40 ± 0.5 | >120 | 7.95 ± 3.41 | 5.21 ± 1.33 | 1.08 ± 0.25 | 5.38 ± 2.06 | | Hole-board test | Number of holes explored over 5 min | 7 ± 1 | 0 | 4.84 ± 1.57 | 3.96 ± 1.95 | 5.12 ± 1.40 | 3.60 ± 0.67 | | Rotarod test | Time spent on stem (s) | 120 ± 0 | 1.2 ± 0.9 | 120 ± 0 | 120 ± 0 | 120 ± 0 | 120 ± 0 |
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