Synthesis of Surfactants Derived from 2-Mercaptobenzimidazole and Study of Their Acute Toxicity and Analgesic and Psychotropic Activities

Table 5

Results of the sedative activity of the products 4 and 5 at the doses 200 and 400 mg/kg.

		Witness	Bromazepam	4 (200 mg/kg)	4 (400 mg/kg)	5 (200 mg/kg)	5 (400 mg/kg)
Traction test	Percentage of falls (%)	0	100	0	0	0	0
	Average fall time (s)	0	10.0 ± 0.9	0	0	0	0
	Average recovery time (s)	0.5 ± 0.1	0	1.08 ± 0.25	1.51 ± 0.78	1.66 ± 0.18	1.20 ± 0.50
Chemney test	Average time to climb the chemney (s)	3.40 ± 0.5	>120	5.17 ± 1.71	4.82 ± 1.50	3.76 ± 1.31	6.61 ± 2.81
Hole-board test	Number of holes explored over 5 min	7 ± 1	0	5.36 ± 0.92	3.88 ± 1.51	4.88 ± 1.30	4.72 ± 1.40
Rotarod test	Time spent on stem (s)	120 ± 0	1.2 ± 0.9	120 ± 0	120 ± 0	120 ± 0	120 ± 0

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