In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice

Table 3

Rectal temperature of infected mice treated with 80% methanol and aqueous extracts of Terminalia brownii in the 4-day suppressive test.

Test substances	Dose (mg/kg/day)	Pretreatment rectal temperature	Posttreatment rectal temperature	Percentage change %
Distilled water	0.2 ml	35.9 ± 0.34	33.3 ± 0.31	−0.4
Methanol extract	100 mg	35.8 ± 0.28	35.8 ± 0.22	+0.1^a^c^d
	200 mg	36.5 ± 0.26	36.5 ± 0.23	+0.3^a^c^d
	400 mg	37.0 ± 0.21	37.5 ± 0.32	+0.5^a^c^d
Aqueous extract	100 mg	36.4 ± 0.24	33.3 ± 0.25	−0.5
	200 mg	36.9 ± 0.20	34.3 ± 0.19	−0.3
	400 mg	35.9 ± 0.17	33.4 ± 0.18	−0.4
Chloroquine	25 mg	36.2 ± 0.15	36.7 ± 0.12	+0.7^a^b^c

Values are presented as M ± SEM; n = 5. ; ; a = compared to negative control; b = compared to 80% methanol extract; c = compared to aqueous extract; d = compared to chloroquine.