Structural Predictive Model of Presenilin-2 Protein and Analysis of Structural Effects of Familial Alzheimer’s Disease Mutations

<div>Alignment of the PS1 protein and the hypothetical model of PS2. (a) Alignment of primary sequences in FASTA. (b) Global three-dimensional alignment. Template protein PS1 Subunit B with ID: 6IYC (violet), complete model of protein PS1 with Phyre2 (dark blue), complete model of protein PS2 with I-Tasser and refinement FGMD (cyan), modeled active site of PS2 (red), and active site of PS1 (yellow).</div>

Biochemistry Research International

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Figure 2

Figure 2: Structural Predictive Model of Presenilin-2 Protein and Analysis of Structural Effects of Familial Alzheimer’s Disease Mutations 