Structural Predictive Model of Presenilin-2 Protein and Analysis of Structural Effects of Familial Alzheimer’s Disease Mutations

Figure 5

Analysis of selected mutations from various approaches. (a) Top view of the cross sections of the wild-type PS2 (pale blue), and the two mutations Met239Ile and Met239Val that affect the canonical function analyzed in the pore (dark blue). (b) Hydropathic index of the mutations evaluated in PS2.

(a)

(b)