Biochemistry Research International

Endoplasmic Reticulum Stress and Lipid Metabolism

Publishing date
01 May 2012
Submission deadline
01 Nov 2011

Lead Editor

1Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA

2Center for Molecular Medicine & Genetics, Department of Immunology and Microbiology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI , USA

3Department of Respiratory Medicine, Hannover Medical School, Feodor Lynen Street 23, 30625 Hannover, Germany

4College of Pharmacy, Wenzhou Medical College, Wenzhou, Zhejiang, China

Endoplasmic Reticulum Stress and Lipid Metabolism


Endoplasmic reticulum (ER) is the principle site for protein folding and assembly, Ca2+ storage and signaling, and biosynthesis of lipids and steroids. Disruption of ER homeostasis imposes stress on the ER and subsequently leads to accumulation of unfolded or misfolded proteins in the ER lumen-a condition termed “ER stress.” In response to ER stress, the ER has evolved highly specific signaling pathways collectively called “unfolded protein response (UPR).” Recent research indicates that the UPR is critically involved in the pathogenesis of various human diseases associated with lipid dysregulation, such as dyslipidemia, obesity, diabetes, alcoholic and nonalcoholic fatty liver disease, and cardiovascular diseases. Understanding the impact of ER stress signaling pathways on lipid metabolism will provide important information for the prevention and treatment of these common human diseases in modern world.

We invite front-running (or leading) investigators to contribute original research articles as well as review articles that seek to define roles of ER stress response in lipid metabolism. We are particularly interested in articles that explore the aspects of ER stress-mediated signaling pathways in regulating lipid metabolism relevant to human disease. Potential topics include, but are not limited to:

  • Roles and mechanisms of ER stress response in lipid metabolism
  • New cellular and animal models to manipulate the ER stress signaling
  • Involvement of ER stress response in alcoholic and nonalcoholic fatty liver diseases
  • Development of potential therapeutics for dyslipidemia by targeting ER stress response pathways
  • Clinical evidence of ER stress response in dyslipidemia

Before submission authors should carefully read over the journal's Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:

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