Table of Contents
Biotechnology Research International
Volume 2016, Article ID 8589270, 6 pages
http://dx.doi.org/10.1155/2016/8589270
Research Article

Chimerism Analysis of Cell-Free DNA in Patients Treated with Hematopoietic Stem Cell Transplantation May Predict Early Relapse in Patients with Hematologic Malignancies

1Oncology Centre, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
2Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
3Pediatric Hematology/Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
4Hematology/Oncology, NeoGenomics Laboratories, Irvine, CA 92618, USA

Received 13 September 2015; Revised 9 January 2016; Accepted 12 January 2016

Academic Editor: Gabriel A. Monteiro

Copyright © 2016 Mahmoud Aljurf et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. D. Thomas, R. Storb, R. A. Clift et al., “Bone marrow transplantation,” The New England Journal of Medicine, vol. 292, no. 16, pp. 832–843, 1975. View at Publisher · View at Google Scholar · View at Scopus
  2. J. O. Armitage, “Bone marrow transplantation,” The New England Journal of Medicine, vol. 330, no. 12, pp. 827–838, 1994. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Frederick and M. D. Appelbaum, “Hematopoietic-cell transplantation,” The New England Journal of Medicine, vol. 357, pp. 1472–1473, 2007. View at Publisher · View at Google Scholar
  4. S. Shenoy, T. Mohanakumar, G. Todd et al., “Immune reconstitution following allogeneic peripheral blood stem cell transplants,” Bone Marrow Transplantation, vol. 23, no. 4, pp. 335–346, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Novitzky, G. M. Davison, G. Hale, and H. Waldmann, “Immune reconstitution at 6 months following T-cell depleted hematopoietic stem cell transplantation is predictive for treatment outcome,” Transplantation, vol. 74, no. 11, pp. 1551–1559, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Storek, R. P. Witherspoon, and R. Storb, “T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life,” Bone Marrow Transplantation, vol. 16, no. 3, pp. 413–425, 1995. View at Google Scholar · View at Scopus
  7. W. Frankel, A. Chan, R. E. T. Corringham, S. Shepherd, A. Rearden, and J. Wang-Rodriguez, “Detection of chimerism and early engraftment after allogeneic peripheral blood stem cell or bone marrow transplantation by short tandem repeats,” American Journal of Hematology, vol. 52, no. 4, pp. 281–287, 1996. View at Publisher · View at Google Scholar · View at Scopus
  8. A. H. Elmaagacli, D. W. Beelen, H. W. Becks et al., “Molecular studies of chimerism and minimal residual disease after allogeneic peripheral blood progenitor cell or bone marrow transplantation,” Bone Marrow Transplantation, vol. 18, no. 2, pp. 397–403, 1996. View at Google Scholar · View at Scopus
  9. S.-J. Choi, K.-H. Lee, J.-H. Lee et al., “Prognostic value of hematopoietic chimerism in patients with acute leukemia after allogeneic bone marrow transplantation: a prospective study,” Bone Marrow Transplantation, vol. 26, no. 3, pp. 327–332, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Serrano, J. Roman, J. Sanchez et al., “Molecular analysis of lineage-specific chimerism and minimal residual disease by RT-PCR of p210BCR-ABL and p190BCR-ABL after allogeneic bone marrow transplantation for chronic myeloid leukemia: increasing mixed myeloid chimerism and p190BCR-ABL detection precede cytogenetic relapse,” Blood, vol. 95, no. 8, pp. 2659–2665, 2000. View at Google Scholar · View at Scopus
  11. A. H. Elmaagacli, K. Runkel, N. Steckel et al., “A comparison of chimerism and minimal residual disease between four different allogeneic transplantation methods in patients with chronic myelogenous leukemia in first chronic phase,” Bone Marrow Transplantation, vol. 27, no. 8, pp. 809–815, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Lawler, P. Humphries, and S. R. McCann, “Evaluation of mixed chimerism by in vitro amplification of dinucleotide repeat sequences using the polymerase chain reaction,” Blood, vol. 77, no. 11, pp. 2504–2514, 1991. View at Google Scholar · View at Scopus
  13. I. Buño, P. Nava, A. Simón et al., “A comparison of fluorescent in situ hybridization and multiplex short tandem repeat polymerase chain reaction for quantifying chimerism after stem cell transplantation,” Haematologica, vol. 90, no. 10, pp. 1373–1379, 2005. View at Google Scholar · View at Scopus
  14. M. Adamek, G. Opelz, K. Klein, C. Morath, and T. H. Tran, “A fast and simple method for detecting and quantifying donor-derived cell-free DNA in sera of solid organ transplant recipients as a biomarker for graft function,” Clinical Chemistry and Laboratory Medicine, vol. 53, pp. 1434–6621, 2015. View at Publisher · View at Google Scholar
  15. J. Beck, M. Oellerich, U. Schulz et al., “Donor-derived cell-free DNA is a novel universal biomarker for allograft rejection in solid organ transplantation,” Transplantation Proceedings, vol. 47, no. 8, pp. 2400–2403, 2015. View at Publisher · View at Google Scholar
  16. R. Sachidanandam, D. Weissman, S. C. Schmidt et al., “A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms,” Nature, vol. 409, no. 6822, pp. 928–933, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. J. R. Gomez, J. Serrano, A. Jiménez et al., “Myeloid mixed chimerism is associated with relapse in bcr-abl positive patients after unmanipulated allogeneic bone marrow transplantation for chronic myelogenous leukemia,” Haematologica, vol. 85, no. 2, pp. 173–180, 2000. View at Google Scholar · View at Scopus
  18. P. Bader, J. Beck, A. Frey et al., “Serial and quantitative analysis of mixed hematopoietic chimerism by PCR in patients with acute leukemias allows the prediction of relapse after allogeneic BMT,” Bone Marrow Transplantation, vol. 21, no. 5, pp. 487–495, 1998. View at Publisher · View at Google Scholar · View at Scopus