A Composite Synergistic Systems Model for Exploring the Efficacies of Different Chemotherapeutic Strategies in Cancer

Figure 2

Simulation runs in different conditions (as indicated by different rows): (I) freely growing condition, (II) MTD strategy application, (III) MTD with intermittent HSC transplantation, (IV) AAG application, (V) MTD with intermittent HSC transplantation followed by AAG application, and (VI) MCT (with Im and Ihs) application. In all the plots of 1st column (a), 2nd column (b), and 3rd column (c), 𝑌-axes indicate the therapeutic profile (applied dose/unit amount) (drug profile (dose) (chemotherapeutic/AAG drug with blue line) and HSC transplantation profile (with pink line and asterisks) and the arrow in plot Va indicates the starting of AAG drug application), doubling time of sensitive (red) and resistive (black) cell types (FD model (indicated by straight line) and VG model (indicated by line with diamond/star)), and PBL TAF (ng/μL) dynamics, respectively. In all plots, 𝑥-axis indicates time (in days).