Identification of Plant Homologues of Dual Specificity Yak1-Related Kinases

Figure 4

Sequence comparison of the activation loop (P+1 site) and the beginning of helix_G in the known DYRK family kinases, potential plant homologues and some other CMGC kinases. Subdomain VIII was specified according to Hanks and Hunter [21]. DYRK1A, DYRK2, DYRK3, and DYRK4-Dual Specificity Tyrosine-Phosphorylation-Regulated Kinases from H. sapiens; HIPK1 and HIPK2-Homeodomain-interacting protein kinases 1 and 2 from H. sapiens; dmMNB-Serine/threonine-protein kinase minibrain from D. melanogaster; scYAK1-Dual Specificity Protein Kinase YAK1 from Saccharomyces cerevisiae; acYak1-likely protein kinase Yak1 from C. albicans; ddYakA-probable serine/threonine-protein kinase yakA (dagB) from D. discoideum; ehDYRK-DYRK family protein kinase from Entamoeba histolytica; lmDYRK-DYRK family protein kinase from Leishmania mansoni; MK01-Mitogen-activated protein kinase 1 (MAP kinase subfamily) from H. sapiens; FUS3-Mitogen-activated protein kinase FUS3 (MAP kinase subfamily) from S. cerevisiae; PKR-Interferon-induced, double-stranded RNA-activated protein kinase (GCN2 subfamily) from H. sapiens. Plant homologues: A9U0E5_PHYPA, A9RDR5_PHYPA, A9TA59_PHYPA, and A9TKQ3_PHYPA from P. patens; Q8RWH3_ARATH from A. thaliana; D7MHY5_ARALL from A. lyrata; C0PR87_PICSI from Picea sitchensis; B9SDF7_RICCO from Ricinus communis; C1MRI0_MICPC from Micromonas pusilla; Q00ZG2_OSTTA and Q019C0_OSTTA from O. tauri; A4RXI5_OSTLU from O. lucimarinus; D8RDP5_SELML and D8RRY9_SELML from S. moellendorffii.