Identification of Plant Homologues of Dual Specificity Yak1-Related Kinases

Figure 6

Superimposition of Protein Data Bank structures of Human Dual Specificity Tyrosine-Phosphorylation-Regulated Kinases in active state (1, 2, 3) and models of human DYRK1A (4) and reconstructed plant homologues from P. patens (5) and A. thaliana (6) in YxxxS region. The conformation of residues match human DYRK1A Y321 of 3D-models of plant homologues was similar to that in inactive state (Y321) of Human DYRK1A. 1—Human Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A (PDB: 2VX3) in active state; 2—Human Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 (3K2L) in active state; 3—Human Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 (3KVW) in active state; 4—inactive Human DYRK1A; 5—inactive plant DYRK1A homologue from P. patens (A9U0E5); 6—inactive plant DYRK1A homologue from A. thaliana (Q8RWH3).