Critical Care Research and Practice / 2010 / Article / Tab 1

Clinical Study

Epidemiology, Prognosis, and Evolution of Management of Septic Shock in a French Intensive Care Unit: A Five Years Survey

Table 1

Mortality risk factors in septic shock patients: monovariate analysis COPD: chronic obstructive pulmonary disease, SAPS: simplify acute physiology score, SOFA: sepsis-related organ failure assessment score, ICU: intensive care unit, RRT: renal replacement therapy, prothrombin ratio (PR).

Survivors 146 (45.6)Deceased174 (54.4)P

Comorbidities (%)
Chronic cardiac failure21(14.4)36(21).1233
Diabete mellitus29(19.9)40(23.4).4479
COPD35(23.9)45(26.3).6321
Chronic liver failure11(7.5)24(14).0656
Chronic alcoolism28(19.1)57(33.3).0046
Chronic renal failure6(4.1)10(5.8).4810
Non hematologic malignancy16(10.9)20(11.6).8367
Hematologic malignancy16(10.9)16(9.3).6369
Immunosuppression25(17.1)24(14).4484
Clinical presentation
Male sex (%)92(63)111(63.8).8853
Age (years) (mean SD) .0001
Lactate (meq/l) (mean SD) .0001
Platelet count (1000/mm³) (mean SD) .7813
Creatinine (mg/l) (mean SD) .4825
Bilirubine (mg/l) (mean SD) .0157
PR (%) (mean SD) .0001
pH (mean SD) .0007
PaO2/FiO2 (mean SD) .0021
SAPS II (mean SD) .0001
SOFA score (mean SD) .0002
Respiratory failure (%)123(84.2)153(88.4).2746
Renal failure (%)30(20.5)53(31.1).0323
Coagulation failure (%)21(14.3)29(17.2).4869
Hepatic failure (%)1(0.7)10(6).0108
Neurologic failure (%)40(28.5)70(41.6).0169
Management
Time from shock to ICU admission (hours) (mean SD) .6034
Adapted antibiotic therapy (%) (mean SD)138(97.8)154(96.8).7269
Time from sepsis to adapted antibiotic therapy (hours) (mean SD) .1426
Adequate antibiotic therapy (%)89(92.7)76(83.5).0512
Time from sepsis to adequate antibiotic therapy (hours) (mean SD) .1698
Mechanical ventilation (%)116(79.4)166(95.9) .0001
Noninvasive ventilation (%)12(8.6)27(15.6).0614
Time from shock to intubation (hours) (mean SD) .4050
RRT (%)41(28)57(33.1).3304
Time from shock to RRT (hours) (mean SD) .9216
Cristalloid volume expansion at 6 hours of sepsis (mL) (mean SD) .0135
Cristalloid volume expansion at 24 hours of sepsis (mL) (mean SD) .0001
Hydrocortisone (%)123(84.2)147(84.4).9538
Time from shock to initiation of hydrocortisone (hours) (mean SD) .5985
Activated proteine C (%)13(8.9)8(4.6).1246
Intensive insulin therapy (%)94(64.3)86(49.4).0072
Enteral nutrition (%)101(70.6)67(51.1).0009
Parenteral nutrition (%)39(27.2)29(22.1).3256
Time from shock to initiation of nutrition (days) (mean SD) .7918

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