Two-Hour Lactate Clearance Predicts Negative Outcome in Patients with Cardiorespiratory Insufficiency

Table 1

Patient characteristics.

Variables	Patients (𝑛=95)	Positive outcome (𝑛=67)	Negative outcome (𝑛=28)	𝑃
Age (mean ± SD)	76.1±9.4	75.5±9.2	77.8±9.8	NS
M/F	43/52	28/39	5/8	NS
Apache II score	19.4±4.6	19.3±4.2	19.8±5.3	NS
Vital parameters
Heart rate bpm	114±30.2	117.3±27.8	106.0±34.7	NS
Respiratory rate	34.4±6.8	35.4±6.3	32.3±7.6	NS
MAP mmHg	113.5±32.8	115.6±29.1	94.0±29.3	𝑃<.05^∗
Laboratory values
WBC, mm^3	13.3±5.4	13.3±5.3	13.0±5.8	NS
HTC, %	37.8±7.5	38.5±7.2	34.2±8.2	NS
Creatinine, mg/dL	1.37±0.6	1.36±0.75	1.43±0.3	NS
pH	7.25±0.14	7.24±0.08	7.26±0.16	NS
pO2 , mmHg	63.4±22.5	67.0±33.1	61.9±16.3	𝑃<.05^∗
pCO2 , mmHg	51.4±20.6	51.1±17.6	52.8±26.6	NS
HCO3 , mEq/L	21.5±5.8	21.2±5.1	22.5±7.1	NS
Lactate start, mmol/L	4.7±2.6	4.7±2.4	4.7±2.9	NS
Lactate 2 h, mmol/L	3.0±2.0	2.2±0.9	4.7±2.8	𝑃<.05^∗
Lactate clearance at 2 hours(%)	27±43	43±30	−11±47	𝑃<.05^∗

* 𝑃<.05, Student 𝑇-test; NS, Not Significant.
MAP: mean arterial pressure, WBC: white blood count, HTC: hematocrit.