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Critical Care Research and Practice
Volume 2011 (2011), Article ID 631062, 7 pages
Clinical Study

Assessment of Procalcitonin to Predict Outcome in Hypothermia-Treated Patients after Cardiac Arrest

1Department of Anaesthesia and Intensive Care, Luxembourg Medical Centre (CHL), 1210 Luxembourg, Luxembourg
2Laboratory of Cardiovascular Research, Public Research Centre for Health (CRP-Sante), 1150 Luxembourg, Luxembourg
3Department of Clinical Biology, Luxembourg Medical Centre (CHL), 1210 Luxembourg, Luxembourg

Received 25 May 2011; Revised 14 July 2011; Accepted 10 August 2011

Academic Editor: Romergryko G. Geocadin

Copyright © 2011 Pascal Stammet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Determine the potential of procalcitonin (PCT) to predict neurological outcome after hypothermia treatment following cardiac arrest. Methods. Retrospective analysis of patient data over a 2-year period. Mortality and neurological outcome of survivors were determined 6 months after cardiac arrest using the Cerebral Performance Category (CPC) score. Results. Data from 53 consecutive patients were analyzed. Median age was 63 (54–71) and 79% were male. Twenty-seven patients had good outcome (CPC ≤ 2) whereas 26 had severe neurological sequelae or died (CPC 3–5). At 48 h, after regaining normothermia, PCT was significantly higher in patients with bad outcome compared to those with good outcome: 3.38 (1.10–24.48) versus 0.28 (0–0.75) ng/mL ( 𝑃 < 0 . 0 0 1 ). PCT values correlated with bad neurological outcome ( 𝑟 = 0 . 5 4 , 𝑃 = 0 . 0 0 0 0 4 ) and predicted outcome with an area under the curve of 0.84 (95% CI 0.73–0.96). A cutoff point of 1 ng/mL provided a sensitivity of 85% and a specificity of 81%. Above a PCT level of 16 ng/mL, no patient regained consciousness. PCT provided an additive value over simplified acute physiology score II. Conclusions. PCT might be an ancillary marker for outcome prediction after cardiac arrest treated by induced hypothermia.