Positive Fluid Balance Is Associated with Higher Mortality and Prolonged Mechanical Ventilation in Pediatric Patients with Acute Lung Injury

Table 2

(a) Multivariate results for mortality

	Odds ratio (95% C.I.)	P-Value
PaO2/FiO2^1	0.91 (0.82, 1.00)	.05
Other OSF^2	1.90 (1.45, 2.49)	<.01
CNS Failure	7.46 (3.60, 15.45)	<.01
Fluid Balance^3	1.08 (1.01, 1.15)	.02

(b) Multivariate results for ventilator-free days

	Coefficient (95% C.I.)	P-Value
PaO2/FiO2^1	0.43 (0.14, 0.72)	<.01
Other OSF^2	−2.21 (−3.07, −1.35)	<.01
CNS Failure	−6.33 (−9.06, −3.61)	<.01
Fluid Balance^3	−0.21 (−0.39, −0.04)	.02

¹PaO2/FiO2 measured in 20 point increases.
²Nonpulmonary, non-CNS organ system failure.
³Fluid Balance measured in 10 mL/kg/day increments.