Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice
Bronchoalveolar lavage fluid thrombin-antithrombin complex (TATc) and plasminogen activator inhibitor (PAI)-1 levels in control mice (C) and mice ventilated for 5 hours with lower tidal volumes (L) or higher (H). Each group consisted of heterozygote TF knockout mice (TF+/−) and their wild-type littermates (TF+/+). Data represent medians and interquartile range of six mice. * versus TF+/+ mice.
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