Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice
Systemic levels of interleukin (IL)-6 and keratinocyte-derived chemokine (KC) in plasma after 5 hours in control mice (C) and mice ventilated for 5 hours with lower tidal volumes (L) or higher VT (H). Each group consisted of heterozygote TF knock-out mice (TF+/−) and their wild-type littermates (TF+/+). Data represent medians and interquartile range of six mice. Differences between TF+/− and TF+/+ are not statistically significant.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.