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Critical Care Research and Practice
Volume 2012, Article ID 278483, 5 pages
Review Article

Novel Approaches to Surfactant Administration

1University Hospital of North Tees and Durham University, Hardwick Road, Stockton-on-Tees, Cleveland, OH TS19 8PE, UK
2Division of Neonatal-Perinatal Medicine, C. S. Mott Children’s Hospital, University of Michigan Health System, Ann Arbor, MI 48109-4254, USA

Received 4 September 2012; Accepted 19 November 2012

Academic Editor: Hercília Guimarães

Copyright © 2012 Samir Gupta and Steven M. Donn. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Surfactant replacement therapy has been the mainstay of treatment for preterm infants with respiratory distress syndrome for more than twenty years. For the most part, surfactant is administered intratracheally, followed by mechanical ventilation. In recent years, the growing interest in noninvasive ventilation has led to novel approaches of administration. This paper will review these techniques and the associated clinical evidence.