The Microcirculation Is Unchanged in Neonates with Severe Respiratory Failure after the Initiation of ECMO Treatment
Table 3
Microcirculatory values.
T1 ECMO
T2 ECMO
T1 Controls
T2 Controls
value at baseline*
value over time†
FCD [cm/cm2]
4.5 (2.4–7.7)
4.3 (2.8–7.4)
5.0 (1.8–7.2)
2.4 (1.4–4.2)
0.811
<0.001
MFI Large
2.76 (2.50–3.00)
2.88 (2.34–3.00)
2.92 (2.50–3.00)
3.00 (2.63–3.00)
0.266
0.367
MFI Medium
2.67 (2.13–3.00)
2.75 (2.13–3.00)
2.75 (2.38–3.00)
2.81 (2.50–3.00)
0.254
0.411
MFI Small
2.75 (2.06–3.00)
2.75 (2.08–3.00)
2.88 (2.44–3.00)
2.90 (2.63–3.00)
0.574
0.090
HI Large
0.10 (0.00–0.30)
0.09 (0.00–0.40)
0.09 (0.00–0.29)
0.00 (0.00–0.26)
0.951
0.2406
HI Medium
0.14 (0.00–0.60)
0.11 (0.00–0.35)
0.10 (0.00–0.51)
0.00 (0.00–0.27)
0.736
0.2421
HI Small
0.18 (0.00–0.73)
0.09 (0.00–0.37)
0.09 (0.00–0.40)
0.00 (0.00–0.17)
0.579
0.0971
Data are presented as median and range.
*Intergroup differences at T1 were assessed using Mann-Whitney test. † For the time-dependent variables, differences at T2 were assessed using ANCOVA with the baseline measurement as covariate. FCD: functional capillary density, MFI: microvascular flow index, HI: heterogeneity index.