|
Reference
(year) | Type of patients
() | VT-PEEP | Main results |
| | mL/kg cm H2O | |
|
|
Non-cardiac surgery | |
| Fernández-Pérez et al. (2006) [42] Observational | Pneumonectomy (170) | VT 8.3 versus 6.7 | 18% postoperative ARF VT was a risk factor for ARF |
| Michelet et al. (2006) [43] RCT | Esophagectomy (52) | VT 9/9-PEEP 0
VT 9/5-PEEP 5 | ↘ inflammatory markers
↗ oxygenation, ↘ MV duration |
| Lee et al. (1990) [41] RCT | Mixed postop patients (103) | VT 12 versus 6 | Trend for ↘ pulmonary infections
and ↘ MV duration |
| Wrigge et al. (2000) [55] RCT | Elective surgeries (39) | VT 15-PEEP 0
VT 6-PEEP 0
VT 6-PEEP 10 | No difference in inflammatory markers 1 h after surgery |
| Wrigge et al. (2004) [26]RCT | Abdominal and thoracic surgeries (64) | VT 12–15-PEEP 0
VT 6-PEEP 10 | No difference in inflammatory markers 3 hrs after surgery |
| Choi et al. (2006) [56] RCT | Prolonged surgeries (40) | VT 12-PEEP 0
VT 6-PEEP 10 | ↘ coagulation activation after 5 hrs of MV |
| Weingarten et al. (2010) [44] RCT | Major abdominal surgeries (40) | VT 10-PEEP 0
VT 6-PEEP 12 | Improved respiratory mechanics and oxygenation, no difference in biomarkers |
|
|
Cardiac surgery |
| Koner et al. (2004) [51] RCT | CABG (44) | VT 10-PEEP 0
VT 6-PEEP 5 | No difference on inflammation
↗ oxygenation with PEEP |
| Wrigge et al. (2005) [52] RCT | CABG (44) | VT 6-PEEP 10
VT 12-PEEP 7
VT 6-PEEP 9 | ↘ TNF in BAL |
| Reis Miranda et al. (2005) [50] RCT | CABG (62) | VT 6–8-PEEP 5
VT 4–6-PEEP 10 | More rapid ↘ in proinflammatory cytokines |
| Zupancich et al. (2005) [49] RCT | CABG (40) | VT 10–12*-PEEP 2-3
VT 8*-PEEP 10 | ↘ proinflammatory cytokines after cardiopulmonary bypass |
| Sundar et al. (2011) [53] RCT | CABG, Valves (149) | VT 10-PEEP > 5
VT 6-PEEP > 5 | Less intubated patients after 6 hrs
Less reintubation |
| Lellouche et al. (2010) [54] Observational | CABG, Valves (3434) | VT < 10 versus 10–12 versus > 12 | ↗ organ dysfunction and ↗ ICU length of stay with high and traditional VT |
|
