Review Article
Low Tidal Volume Ventilation in Patients without Acute Respiratory Distress Syndrome: A Paradigm Shift in Mechanical Ventilation
Table 2
Impact of ventilation strategy for critically ill intensive care unit patients.
| Reference (year) | Type of patients () | VT-PEEP | Main results | | | mL/kg cm H2O | |
|
Intensive care unit patients | | Gajic et al. (2004) [35] Cohort | Medical/surgical (332) | | OR for ALI = 1.3 for every 1 mL > 6 mL/kg |
| Gajic et al. (2005) [36] Retrospective | Medical/surgical (3261) | | OR for ARDS = 2.6 with VT > 700 mL |
| Determann et al. (2010) [37] RCT | Medical/surgical (150) | VT 10 versus 6 | Relative risk for developing ALI was 5.1 with high VT ↓ inflammatory markers |
| Mascia et al. (2010) [38] RCT | Organ Donors (118) | VT 10–12-PEEP 3–5 VT 6–8-PEEP 8–10 | More eligible and harvested lungs with low VT |
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RCT: randomized controlled studies. MV: mechanical ventilation. VT: tidal volume. ALI: acute lung injury. ARDS: acute respiratory distress syndrome.
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