Low Tidal Volume Ventilation in Patients without Acute Respiratory Distress Syndrome: A Paradigm Shift in Mechanical Ventilation

Table 2

Impact of ventilation strategy for critically ill intensive care unit patients.

Reference; (year)	Type of patients; (𝑛)	VT-PEEP	Main results
		mL/kg  cm H2O
Intensive care unit patients
Gajic et al. (2004) [35] Cohort	Medical/surgical (332)		OR for ALI = 1.3 for every 1 mL > 6 mL/kg
Gajic et al. (2005) [36] Retrospective	Medical/surgical; (3261)		OR for ARDS = 2.6 with VT > 700 mL
Determann et al. (2010) [37] RCT	Medical/surgical; (150)	VT 10 versus 6	Relative risk for developing ALI was 5.1 with high VT; ↓ inflammatory markers
Mascia et al. (2010) [38] RCT	Organ Donors; (118)	VT 10–12-PEEP 3–5; VT 6–8-PEEP 8–10	More eligible and harvested lungs with low VT

RCT: randomized controlled studies. MV: mechanical ventilation. VT: tidal volume. ALI: acute lung injury. ARDS: acute respiratory distress syndrome.