Review Article

Goal-Directed Mechanical Ventilation: Are We Aiming at the Right Goals? A Proposal for an Alternative Approach Aiming at Optimal Lung Compliance, Guided by Esophageal Pressure in Acute Respiratory Failure

Figure 2

Negative transpulmonary pressure at end-expiration may subject the lungs to cyclic collapse. Black arrow indicates the point where PEEP was raised to a level that would ensure a slightly positive end-expiratory transpulmonary pressure. = airway opening pressure, = esophageal pressure, = transpulmonary pressure.
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