Increased Extravascular Lung Water Reduces the Efficacy of Alveolar Recruitment Maneuver in Acute Respiratory Distress Syndrome
Table 4
Blood gases, hemodynamics, and parameters of mechanical ventilation in patients with low and increased extravascular lung water index.
Parameter
EVLWI <10 mL/kg ()
EVLWI ≥10 mL/kg ()
P
PaO2/FiO2 at baseline, mm Hg
117 ± 34
159 ± 47
0.09
PaO2/FiO2 after RM, mm Hg
146 (122–177)
158 (122–168)
0.46
PaO2/FiO2 stability of RM, mm Hg
134 ± 58
149 ± 46
0.58
Changes in PaO2/FiO2 within the period of stability assessment, %
−14((−1)–(−5))
−18((−37)–(−9))
0.68
PaCO2 at baseline, mm Hg
45 ± 8
45 ± 8
0.89
PaCO2 after RM, mm Hg
49 ± 13
48 ± 9
0.54
PaCO2 stability of RM, mm Hg
43 ± 6
48 ± 8
0.29
CI, L/min/m2
0.95
MAP, mm Hg
75 (66–106)
88 (71–99)
0.40
SVRI, dyn sec cm−5/m2
1717 (1089–2144)
1597 (1285–2238)
0.75
HR, beat/min
101 (97–105)
103 (84–133)
0.92
GEDVI, mL/m2
654 ± 92
714 ± 140
0.39
EVLWI, mL/kg
8.2 (6.0–9.1)
15.8 (11.2–17.8)
0.002
FiO2, %
50 (50–80)
50 (50–60)
0.51
Tidal volume, mL
504 ± 34
439 ± 58
0.04
Minute ventilation, L/min
11.6 (11.4–14.6)
9.9 (8.4–12.0)
0.06
Dynamic respiratory compliance, mL/cm H2O
29 (26–59)
28 (24–35)
0.67
Data are presented as mean ± standard deviation, absolute values or median (25th–75th percentile). RM: recruitment maneuver; CI: cardiac index; MAP: mean arterial pressure; SVRI: systemic vascular resistance index; HR: heart rate; GEDVI: global end-diastolic volume index; EVLWI: extravascular lung water index.
