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Critical Care Research and Practice
Volume 2012, Article ID 715265, 6 pages
Research Article

A High Ductal Flow Velocity Is Associated with Successful Pharmacological Closure of Patent Ductus Arteriosus in Infants 22–27 Weeks Gestational Age

Department of Women’s and Children’s Health, Uppsala University Children’s Hospital, Uppsala University, SE-751 85 Uppsala, Sweden

Received 4 September 2012; Revised 10 November 2012; Accepted 10 November 2012

Academic Editor: Gustavo Rocha

Copyright © 2012 Karl Wilhelm Olsson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To identify factors affecting closure of patent ductus arteriosus (PDA) in newborn infants born at 22–27 weeks gestational age (GA) during pharmacological treatment with cyclooxygenase inhibitors. Method. Infants born at 22–27 weeks of GA between January 2006 and December 2009 who had been treated pharmacologically for PDA were identified retrospectively. Medical records were assessed for clinical, ventilatory, and outcome parameters. Echocardiographic examinations during treatment were reviewed. Results. Fifty-six infants were included in the study. Overall success rate of ductal closure with pharmacological treatment was 52%. Infants whose PDA was successfully closed had a higher GA ( weeks versus weeks; and a higher pretreatment left to right maximal ductal flow velocity (1.6 m/s versus 1.1 m/s; ). Correcting for GA, preeclampsia, antenatal steroids, and age at start of treatment, a higher maximal ductal flow velocity was still associated with successful ductal closure (OR 3.04; ). Conclusion. Maximal ductal flow velocity was independently associated with success of PDA treatment.