Research Article
A High Ductal Flow Velocity Is Associated with Successful Pharmacological Closure of Patent Ductus Arteriosus in Infants 22–27 Weeks Gestational Age
Table 3
Treatment characteristics.
| | | Ductus closed () | Ductus persistent () | |
| | Age at treatment start, days (range) | 3 (1–8) | 3 (1–40) | 0.117 | | Indomethacin (%) | 26 (90) | 22 (82) | 0.462 | | Ibuprofen1 (%) | 4 (14) | 6 (22) | 0.497 | | Change in weight, % (range) | 1 (−10–9) | 4 (−12–12) | 0.090 | | Fluid intake, mL/kg/day (range) | 134 (98–168) | 139 (111–203) | 0.354 | |
Part IV, % (range) | 59 (0–85) | 43 (0–89) | 0.468 | | Urine output, mL/kg/h (range) | 2.1 (0.5–4.2) | 2.2 (0.4–4.9) | 0.594 |
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11 versus 1 infants received treatment with both indomethacin and ibuprofen during the same course.
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