Variability in Uremic Control during Continuous Venovenous Hemodiafiltration in Trauma Patients
Table 1
Patient characteristics: Trauma patients with acute kidney injury with continuous renal replacement therapy (CRRT) grouped with and without rhabdomyolysis ().
Total ()
Rhabdomyolysis ()
Not rhabdomyolysis ()
P value
Demographic data
Age (years)
48 (30–65)
35 (23–51)
57 (44–68)
0.01
Male gender
31 (86)
17 (100)
14 (74)
0.02
SAPS II score
41 (32–48)
38 (31–48)
41 (32–49)
0.90
ISS score
34 (26–47)
43 (17–50)
34 (27–41)
0.24
Indication for CRRT
Fluid overload
19 (53)
8 (47)
11 (58)
0.52
Hyperkalemia
20 (56)
9 (53)
11 (58)
0.77
Acidosis
15 (42)
3 (18)
12 (63)
0.01
Uremia
9 (25)
4 (24)
5 (26)
0.85
Rhabdomyolysis
17 (47)
17 (100)
0 (0)
<0.01
Kidney function at start of CRRT
Diuresis (mL/day)
536 (256–1692)
522 (252–2060)
550 (255–1410)
0.80
Serum potassium (mmol/L)
5.0 (4.2–5.5)
4.4 (4.0–5.7)
5.1 (4.8–5.5)
0.20
Serum urea (mmol/L)
17.8 (12.5–28.4)
13.6 (10.6–25.0)
22.2 (16.3–29.8)
0.07
Serum creatinine (μmol/L)
249 (204–376)
247 (198–483)
269 (215–361)
0.95
Serum creatine kinase (U/L)
4638 (460–24414)
24415 (9660–45740)
603 (135–2152)
<0.01
CRRT performance data
Median daily CRRT duration (hours)
18.6 (14.9–21.3)
16.3 (12.4–20.0)
19.7 (15.6–21.8)
0.19
Median Δurea
-0.05 (−0.12–0.09)
-0.06 (−0.19–0.03)
-0.05 (−0.08–0.11)
0.20
Median Δcreatinine
0.05 (−0.04–0.17)
0.03 (−0.17–0.15)
0.12 (0.01–0.17)
0.21
Filter clotting pauses
68 (54)
36 (55)
32 (53)
0.90
Therapeutic pauses
32 (25)
25 (38)
7 (12)
<0.01
Catheter-related pauses
12 (10)
3 (5)
9 (15)
0.05
Filter timeout pauses
7 (6)
1 (2)
6 (10)
0.04
Diagnostic pauses
7 (6)
5 (8)
2 (3)
0.30
Outcome
Dialysis-dependent 3 months
0 (0)
0 (0)
0 (0)
n.c.
Dialysis-dependent 1 year
0 (0)
0 (0)
0 (0)
n.c.
Mortality 3 months
11 (31)
3 (18)
8 (42)
0.11
Mortality 1 year
13 (36)
4 (24)
9 (47)
0.14
Categorical data are presented as number (percent) and compared using Pearson chi-square test. Continuous data are expressed as median (interquartile range) and are compared using 2-tailed Mann-Whitney U test. SAPS II: simplified acute physiology score II. ISS: injury severity score. n.c.: not calculated. See text for other definitions.
