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Critical Care Research and Practice
Volume 2012, Article ID 952168, 13 pages
http://dx.doi.org/10.1155/2012/952168
Review Article

Goal-Oriented Respiratory Management for Critically Ill Patients with Acute Respiratory Distress Syndrome

1Respiratory ICU and LIM-09, Medical School, University of São Paulo, 6 Andar, Avenida Dr. Eneas de Carvalho Aguiar 155, 05403-000 São Paulo, SP, Brazil
2Adult ICU Albert Einstein Hospital, 5 Andar, Avenida Albert Einstein 627, 05652-900 São Paulo, SP, Brazil

Received 2 June 2012; Accepted 19 July 2012

Academic Editor: Lars J. Bjertnaes

Copyright © 2012 Carmen Sílvia Valente Barbas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. G. Ashbaugh, D. B. Bigelow, T. L. Petty, and B. E. Levine, “Acute respiratory distress in adults,” Lancet, vol. 2, no. 7511, pp. 319–323, 1967. View at Google Scholar · View at Scopus
  2. J. F. Murray, M. A. Matthay, J. M. Luce, and M. R. Flick, “An expanded definition of the adult respiratory distress syndrome,” American Review of Respiratory Disease, vol. 138, no. 3, pp. 720–723, 1988. View at Google Scholar · View at Scopus
  3. L. B. Ware and M. A. Matthay, “The acute respiratory distress syndrome,” New England Journal of Medicine, vol. 342, no. 18, pp. 1334–1349, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Esteban, P. Fernández-Segoviano, F. Frutos-Vivar et al., “Comparison of clinical criteria for the acute respiratory distress syndrome with autopsy findings,” Annals of Internal Medicine, vol. 141, no. 6, pp. 440–445, 2004. View at Google Scholar · View at Scopus
  5. C. R. Bernard, “Acute respiratory distress syndrome: a historical perspective,” American Journal of Respiratory and Critical Care Medicine, vol. 172, no. 7, pp. 798–806, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. N. D. Ferguson, F. Frutos-Vivar, A. Esteban et al., “Acute respiratory distress syndrome: underrecognition by clinicians and diagnostic accuracy of three clinical definitions,” Critical Care Medicine, vol. 33, no. 10, pp. 2228–2234, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. L. B. Ware and M. A. Matthay, “Acute pulmonary edema,” New England Journal of Medicine, vol. 353, no. 26, pp. 2788–2796, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. N. D. Ferguson, A. M. Davis, A. S. Slutsky, and T. E. Stewart, “Development of a clinical definition for acute respiratory distress syndrome using the Delphi technique,” Journal of Critical Care, vol. 20, no. 2, pp. 147–154, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. A. P. Wheeler and G. R. Bernard, “Acute lung injury and the acute respiratory distress syndrome: a clinical review,” Lancet, vol. 369, no. 9572, pp. 1553–1564, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. C. S. V. Barbas, “Acute lung injury and acute respiratory distress syndrome: diagnostic hurdles,” Jornal Brasileiro de Pneumologia, vol. 33, no. 4, pp. 25–26, 2007. View at Google Scholar · View at Scopus
  11. L. Su, R. Zhai, C. C. Sheu et al., “Genetic variants in the angiopoietin-2 gene are associated with increased risk of ARDS,” Intensive Care Medicine, vol. 35, no. 6, pp. 1024–1030, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Dushianthan, M. P. W. Grocott, A. D. Postle, and R. Cusack, “Acute respiratory distress syndrome and acute lung injury,” Postgraduate Medical Journal, vol. 87, pp. 612–622, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Donahoe, “Acute respiratory distress syndrome: a clinical review,” Pulmonary Circulation, vol. 1, no. 2, pp. 192–211, 2011. View at Publisher · View at Google Scholar
  14. C. Pierrakos, M. Karanikolas, S. Scolletta, V. Karamouzos, and D. Velissaris, “Acute respiratory distress syndrome: pathophysiology and therapeutic options,” Journal of Clinical Medicine and Research, vol. 4, no. 1, pp. 7–16, 2012. View at Google Scholar
  15. E. K. Bajwa, P. C. Cremer, M. N. Gong et al., “An NFKB1 promoter insertion/deletion polymorphism influences risk and outcome in acute respiratory distress syndrome among caucasians,” PLoS One, vol. 6, no. 5, Article ID e19469, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. G. D. Rubenfeld, E. Caldwell, E. Peabody et al., “Incidence and outcomes of acute lung injury,” New England Journal of Medicine, vol. 353, no. 16, pp. 1685–1693, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. O. Gajic, O. Dabbagh, P. K. Park et al., “Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study,” American Journal of Respiratory and Critical Care Medicine, vol. 183, no. 4, pp. 462–470, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Corrin, “Diffuse alveolar damage, the pathological basis of adult respiratory distress syndrome,” in Pathology of the Lung, B. Corrin, Ed., pp. 121–143, Churchill Livingstone, London, UK, 2000. View at Google Scholar
  19. Y. Fukuda, M. Ishizaki, Y. Masuda, G. Kimura, O. Kawanami, and Y. Masugi, “The role of intra-alveolar fibrosis in the process of pulmonary structural remodeling in patients with diffuse alveolar damage,” in The American Journal of Pathology, vol. 126, pp. 171–182, 1987. View at Google Scholar
  20. C. A. Piantadosi and D. A. Schwartz, “The acute respiratory distress syndrome,” Annals of Internal Medicine, vol. 141, no. 6, pp. 460–470, 2004. View at Google Scholar · View at Scopus
  21. C. Y. Castro, “ARDS and diffuse alveolar damage: a pathologist's perspective,” Seminars in Thoracic and Cardiovascular Surgery, vol. 18, no. 1, pp. 13–19, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. L. B. Ware, “Clinical year in review III: asthma, lung transplantation, cystic fibrosis, acute respiratory distress syndrome,” Proceedings of the American Thoracic Society, vol. 4, no. 6, pp. 489–493, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. H. C. Koenig, B. B. Finkel, S. S. Khalsa et al., “Performance of an automated electronic acute lung injury screening system in intensive care unit patients,” Critical Care Medicine, vol. 39, no. 1, pp. 98–104, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. C. S. V. Barbas, “Introducing automated acute lung injury/acute respiratory distress syndrome electronic screening in intensive care unit practice: is it the future?” Critical Care Medicine, vol. 39, no. 1, pp. 209–210, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. G. R. Bernard, A. Artigas, K. L. Brigham et al., “The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination,” American Journal of Respiratory and Critical Care Medicine, vol. 149, no. 3 I, pp. 818–824, 1994. View at Google Scholar · View at Scopus
  26. A. Artigas, G. R. Bernard, J. Carlet et al., “The American-European consensus conference on ARDS, part 2: ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome,” American Journal of Respiratory and Critical Care Medicine, vol. 157, no. 4, part 1, pp. 1332–1347, 1998. View at Google Scholar · View at Scopus
  27. V. M. Ranieri, G. D. Rubenfeld, B. T. Thompson et al., “Acute respiratory distress syndrome: the Berlin definition,” Journal of the American Medical Association, vol. 307, no. 23, pp. 2526–2533, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Gattinoni, M. Bombino, P. Pelosi et al., “Lung structure and function in different stages of severe adult respiratory distress syndrome,” Journal of the American Medical Association, vol. 271, no. 22, pp. 1772–1779, 1994. View at Publisher · View at Google Scholar · View at Scopus
  29. L. Gattinoni, P. Caironi, P. Pelosi, and L. R. Goodman, “What has computed tomography taught us about the acute respiratory distress syndrome?” American Journal of Respiratory and Critical Care Medicine, vol. 164, no. 9, pp. 1701–1711, 2001. View at Google Scholar · View at Scopus
  30. J. B. Borges, V. N. Okamoto, G. F. J. Matos et al., “Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome,” American Journal of Respiratory and Critical Care Medicine, vol. 174, no. 3, pp. 268–278, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. C. S. V. Barbas, G. F. J. De Matos, M. P. Pincelli et al., “Mechanical ventilation in acute respiratory failure: recruitment and high positive end-expiratory pressure are necessary,” Current Opinion in Critical Care, vol. 11, no. 1, pp. 18–28, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. B. Lachmann, “Open up the lung and keep the lung open,” Intensive Care Medicine, vol. 18, no. 6, pp. 319–321, 1992. View at Publisher · View at Google Scholar · View at Scopus
  33. G. F. J. de Matos, F. Stanzani, R. H. Passos et al., “How large is the lung recruitability in early acute respiratory distress syndrome: a prospective case series of patients monitored by computed tomography,” Critical Care, vol. 16, no. 1, Article ID R4, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Karcz, A. Vitkus, P. J. Papadakos, D. Schwaiberger, and B. Lachmann, “State-of-the-Art Mechanical Ventilation,” Journal of Cardiothoracic and Vascular Anesthesia, vol. 26, no. 3, pp. 486–506, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. C. S. V. Barbas, “Understanding and avoiding ventilator-induced lung injury: lessons from an insightful experimental study,” Critical Care Medicine, vol. 38, no. 12, pp. 2418–2419, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. C. S. Barbas and G. F. de Matos, “Best strategy to recruit primary ARDS: what to look for,” Minerva Anestesiologica, vol. 76, no. 9, pp. 681–683, 2010. View at Google Scholar · View at Scopus
  37. K. Ichikado, H. Muranaka, Y. Gushima et al., “Fibroproliferative changes on high-resolution CT in the acute respiratory distress syndrome predict mortality and ventilator dependency: a prospective observational cohort study,” BMJ Open, vol. 2, no. 2, Article ID e000545, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. G. Bellani, T. Mauri, and A. Pesenti, “Imaging in acute lung injury and acute respiratory distress syndrome,” Current Opinion in Critical Care, vol. 18, no. 1, pp. 29–34, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. N. De Prost, M. R. Tucci, and M. F. Vidal Melo, “Assessment of lung inflammation with 18F-FDG PET during acute lung injury,” American Journal of Roentgenology, vol. 195, no. 2, pp. 292–300, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. G. Bellani, C. Messa, L. Guerra et al., “Lungs of patients with acute respiratory distress syndrome show diffuse inflammation in normally aerated regions: a [18F]-fluoro-2-deoxy-D-glucose PET/CT study,” Critical Care Medicine, vol. 37, no. 7, pp. 2216–2222, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. B. Bouhemad, H. Brisson, M. Le-Guen, C. Arbelot, Q. Lu, and J. J. Rouby, “Bedside ultrasound assessment of positive end-expiratory pressure-induced lung recruitment,” American Journal of Respiratory and Critical Care Medicine, vol. 183, no. 3, pp. 341–347, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. E. L. V. Costa, P. G. Lima, and M. B. R. Amato, “Electrical impedance tomography,” Current Opinion in Critical Care, vol. 15, no. 1, pp. 18–24, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. E. L. V. Costa, J. B. Borges, A. Melo et al., “Bedside estimation of recruitable alveolar collapse and hyperdistension by electrical impedance tomography,” Intensive Care Medicine, vol. 35, no. 6, pp. 1132–1137, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. C. Gomez-Laberge, J. H. Arnold, and G. K. Wolf, “A unified approach for EIT imaging of regional overdistension and atelectasis in acute lung injury,” IEEE Transactions on Medical Imaging, vol. 31, no. 3, Article ID 6127914, pp. 834–842, 2012. View at Publisher · View at Google Scholar · View at Scopus
  45. A. Adler, M. B. Amato, J. H. Arnold et al., “Whither lung EIT: where are we, where do we want to go and what do we need to get there?” Physiological Measurement, vol. 33, no. 5, pp. 679–694, 2012. View at Publisher · View at Google Scholar · View at Scopus
  46. S. P. Keenan, T. Sinuff, D. J. Cook, and N. S. Hill, “Does noninvasive positive pressure ventilation improve outcome in acute hypoxemic respiratory failure? A systematic review,” Critical Care Medicine, vol. 32, no. 12, pp. 2516–2523, 2004. View at Publisher · View at Google Scholar · View at Scopus
  47. Q. Zhan, B. Sun, L. Liang et al., “Early use of noninvasive positive pressure ventilation for acute lung injury: a multicenter randomized controlled trial,” Critical Care Medicine, vol. 40, no. 2, pp. 455–460, 2012. View at Publisher · View at Google Scholar · View at Scopus
  48. R. G. Brower, M. A. Matthay, A. Morris, D. Schoenfeld, B. T. Thompson, and A. Wheeler, “Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome,” New England Journal of Medicine, vol. 342, no. 18, pp. 1301–1308, 2000. View at Publisher · View at Google Scholar · View at Scopus
  49. K. E. A. Burns, N. K. J. Adhikari, A. S. Slutsky et al., “Pressure and volume limited ventilation for the ventilatory management of patients with acute lung injury: a systematic review and meta-analysis,” PLoS ONE, vol. 6, no. 1, Article ID e14623, 2011. View at Publisher · View at Google Scholar · View at Scopus
  50. M. B. P. Amato, T. E. Stewart, L. Brochard et al., “Effects of superimposed driving-pressure on mortality in patients with acute lung injury or acute respiratory distress syndrome,” The Journal of the American Medical Association. In press.
  51. M. B. P. Amato, C. S. V. Barbas, D. M. Medeiros et al., “Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome,” New England Journal of Medicine, vol. 338, no. 6, pp. 347–354, 1998. View at Publisher · View at Google Scholar · View at Scopus
  52. J. Villar, R. M. Kacmarek, L. Pérez-Méndez, and A. Aguirre-Jaime, “A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trial,” Critical Care Medicine, vol. 34, no. 5, pp. 1311–1318, 2006. View at Publisher · View at Google Scholar · View at Scopus
  53. V. M. Ranieri, P. M. Suter, C. Tortorella et al., “Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial,” Journal of the American Medical Association, vol. 282, no. 1, pp. 54–61, 1999. View at Publisher · View at Google Scholar · View at Scopus
  54. S. R. R. Vieira, L. Puybasset, Q. Lu et al., “A scanographic assessment of pulmonary morphology in acute lung injury: significance of the lower inflection point detected on the lung pressure- volume curve,” American Journal of Respiratory and Critical Care Medicine, vol. 159, no. 5 I, pp. 1612–1623, 1999. View at Google Scholar · View at Scopus
  55. J. C. Richard, S. M. Maggiore, B. Jonson, J. Mancebo, F. Lemaire, and L. Brochard, “Influence of tidal volume on alveolar recruitment: respective role of PEEP and a recruitment maneuver,” American Journal of Respiratory and Critical Care Medicine, vol. 163, no. 7, pp. 1609–1613, 2001. View at Google Scholar · View at Scopus
  56. A. A. Maung and L. J. Kaplan, “Airway pressure release ventilation in acute respiratory distress syndrome,” Critical Care Clinics, vol. 27, no. 3, pp. 501–509, 2011. View at Publisher · View at Google Scholar · View at Scopus
  57. A. Modrykamien, R. L. Chatburn, and R. W. Ashton, “Airway pressure release ventilation: an alternative mode of mechanical ventilation in acute respiratory distress syndrome,” Cleveland Clinic Journal of Medicine, vol. 78, no. 2, pp. 101–110, 2011. View at Publisher · View at Google Scholar · View at Scopus
  58. X. Z. Wang, C. J. Lü, F. Q. Gao, X. H. Li, D. Hao, and F. Y. Ning, “Comparison of the effects of BiPAP ventilation combined with lung recruitment maneuvers and low tidal volume A/C ventilation in patients with acute respiratory distress syndrome,” Zhonghua Jie He He Hu Xi Za Zhi, vol. 30, no. 1, pp. 44–47, 2007. View at Google Scholar · View at Scopus
  59. P. M. Spieth, A. R. Carvalho, A. Güldner et al., “Pressure support improves oxygenation and lung protection compared to pressure-controlled ventilation and is further improved by random variation of pressure support,” Critical Care Medicine, vol. 39, no. 4, pp. 746–755, 2011. View at Publisher · View at Google Scholar · View at Scopus
  60. M. Gama De Abreu, P. M. Spieth, P. Pelosi et al., “Noisy pressure support ventilation: a pilot study on a new assisted ventilation mode in experimental lung injury,” Critical Care Medicine, vol. 36, no. 3, pp. 818–827, 2008. View at Publisher · View at Google Scholar · View at Scopus
  61. T. Yoshida, A. Uchiyama, N. Matsuura, T. Mashimo, and Y. Fujino, “Spontaneous breathing during lung-protective ventilation in an experimental acute lung injury model: high transpulmonary pressure associated with strong spontaneous breathing effort may worsen lung injury,” Critical Care Medicine, vol. 40, no. 5, pp. 1578–1585, 2012. View at Publisher · View at Google Scholar · View at Scopus
  62. D. Y. Huang, J. Liu, X. Y. Wu et al., “Effects of neurally adjusted ventilatory adjusted ventilatory assist on prevention of ventilator-induced diaphragmatic dysfunction in acute respiratory distress syndrome rabitts.,” Zhonghua Jie He He Hu Xi Za Zhi, vol. 34, no. 4, pp. 288–293, 2011. View at Google Scholar
  63. X. Y. Wu, Y. Z. Huang, Y. Yang, S. Q. Liu, H. G. Liu, and H. B. Qiu, “Effects of neurally adjusted ventilatory assist on patient-ventilator synchrony in patients with acute respiratory distress syndrome,” Zhonghua Jie He He Hu Xi Za Zhi, vol. 32, no. 7, pp. 508–512, 2009. View at Google Scholar · View at Scopus
  64. S. Sud, M. Sud, J. O. Friedrich et al., “High frequency oscillation in patients with acute lung injury and acute respiratory distress syndrome (ARDS): systematic review and meta-analysis,” BMJ, vol. 340, article c2327, 2010. View at Publisher · View at Google Scholar · View at Scopus
  65. F. Abroug, L. Ouanes-Besbes, F. Dachraoui, I. Ouanes, and L. Brochard, “An updated study-level meta-analysis of randomised controlled trials on proning in ARDS and acute lung injury,” Critical Care, vol. 15, no. 1, article no. R6, 2011. View at Publisher · View at Google Scholar · View at Scopus
  66. L. Gattinoni, E. Carlesso, P. Taccone, F. Polli, C. Guérin, and J. Mancebo, “Prone positioning improves survival in severe ARDS: a pathophysiologic review and individual patient meta-analysis,” Minerva Anestesiologica, vol. 76, no. 6, pp. 448–454, 2010. View at Google Scholar · View at Scopus
  67. P. Squara, J. F. A. Dhainaut, A. Artigas, and J. Carlet, “Hemodynamic profile in severe ARDS: results of the European collaborative ARDS study,” Intensive Care Medicine, vol. 24, no. 10, pp. 1018–1028, 1998. View at Publisher · View at Google Scholar · View at Scopus
  68. H. P. Wiedemann, A. P. Wheeler, G. R. Bernard et al., “Comparison of two fluid-management strategies in acute lung injury,” New England Journal of Medicine, vol. 354, no. 24, pp. 2564–2575, 2006. View at Publisher · View at Google Scholar · View at Scopus
  69. T. M. Bull, B. Clark, K. McFann, and M. Moss, “Pulmonary vascular dysfunction is associated with poor outcomes in patients with acute lung injury,” American Journal of Respiratory and Critical Care Medicine, vol. 182, no. 9, pp. 1123–1128, 2010. View at Publisher · View at Google Scholar · View at Scopus
  70. A. Mekontso Dessap, F. Boissier, R. Leon et al., “Prevalence and prognosis of shunting across patent foramen ovale during acute respiratory distress syndrome,” Critical Care Medicine, vol. 38, no. 9, pp. 1786–1792, 2010. View at Publisher · View at Google Scholar · View at Scopus
  71. W. M. Zapol, M. T. Snider, and J. D. Hill, “Extracorporeal membrane oxygenation in severe acute respiratory failure. A randomized prospective study,” Journal of the American Medical Association, vol. 242, no. 20, pp. 2193–2196, 1979. View at Publisher · View at Google Scholar · View at Scopus
  72. L. Gattinoni, E. Carlesso, and T. Langer, “Clinical review: extracorporeal membrane oxygenation,” Critical Care, vol. 15, no. 6, Article ID 243, 2011. View at Publisher · View at Google Scholar · View at Scopus
  73. D. Brodie and M. Bacchetta, “Extracorporeal membrane oxygenation for ARDS in adults,” New England Journal of Medicine, vol. 365, no. 20, pp. 1905–1914, 2011. View at Publisher · View at Google Scholar · View at Scopus
  74. G. J. Peek, M. Mugford, R. Tiruvoipati et al., “Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial,” The Lancet, vol. 374, no. 9698, pp. 1351–1363, 2009. View at Publisher · View at Google Scholar · View at Scopus
  75. V. M. Ranieri, P. P. Terragni, L. Del Sorbo et al., “Tidal volume lower than 6 ml/kg enhances lung protection: role of extracorporeal carbon dioxide removal,” Anesthesiology, vol. 111, no. 4, pp. 826–835, 2009. View at Publisher · View at Google Scholar · View at Scopus
  76. M. Zimmermann, T. Bein, M. Arlt et al., “Pumpless extracorporeal interventional lung assist in patients with acute respiratory distress syndrome: a prospective pilot study,” Critical Care, vol. 13, no. 1, article no. R10, 2009. View at Publisher · View at Google Scholar · View at Scopus
  77. T. M. Bingold, B. Scheller, T. Wolf et al., “Superimposed high-frequency jet ventilation combined with continuous positive airway pressure/assisted spontaneous breathing improves oxygenation in patients with H1N1-associated ARDS,” Annals of Intensive Care, vol. 2, no. 1, pp. 1–5, 2012. View at Publisher · View at Google Scholar · View at Scopus
  78. T. Varpula, I. Jousela, R. Niemi, O. Takkunen, and V. Pettilä, “Combined effects of prone positioning and airway pressure release ventilation on gas exchange in patients with acute lung injury,” Acta Anaesthesiologica Scandinavica, vol. 47, no. 5, pp. 516–524, 2003. View at Publisher · View at Google Scholar · View at Scopus
  79. G. Rival, C. Patry, N. Floret, J. C. Navellou, E. Belle, and G. Capellier, “Prone position and recruitment manoeuvre: the combined effect improves oxygenation,” Critical Care, vol. 15, no. 3, article no. R125, 2011. View at Publisher · View at Google Scholar · View at Scopus
  80. M. Lubnow, A. Luchner, A. Philipp et al., “Combination of high frequency oscillatory ventilation and interventional lung assist in severe acute respiratory distress syndrome,” Journal of Critical Care, vol. 25, no. 3, pp. 436–444, 2010. View at Publisher · View at Google Scholar · View at Scopus
  81. C. C. Sheu, M. N. Gong, R. Zhai et al., “Clinical characteristics and outcomes of sepsis-related vs non-sepsis-related ARDS,” Chest, vol. 138, no. 3, pp. 559–567, 2010. View at Publisher · View at Google Scholar · View at Scopus
  82. C.-T. Luyt, A. Combes, J.-L. Trouillet, A. Nieszkowska, and J. Chastre, “Virus-induced acute respiratory distress syndrome: epidemiology, management and outcome,” Presse Medicale, vol. 40, no. 12 PART 2, pp. e561–e568, 2011. View at Publisher · View at Google Scholar · View at Scopus
  83. A. G. Proudfoot, M. Hind, and M. J. D. Griffiths, “Biomarkers of acute lung injury: worth their salt?” BMC Medicine, vol. 9, Article ID 132, pp. 132–139, 2011. View at Publisher · View at Google Scholar · View at Scopus
  84. J. G. Clark, J. A. Milberg, K. P. Steinberg, and L. D. Hudson, “Type III procollagen peptide in the adult respiratory distress syndrome. Association of increased peptide levels in bronchoalveolar lavage fluid with increased risk for death,” Annals of Internal Medicine, vol. 122, no. 1, pp. 17–23, 1995. View at Google Scholar · View at Scopus
  85. S. Karlsson, M. Heikkinen, V. Pettilä et al., “Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study,” Critical Care, vol. 14, no. 6, article no. R205, 2010. View at Publisher · View at Google Scholar · View at Scopus
  86. L. Bouadma, C. E. Luyt, F. Tubach et al., “Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial,” The Lancet, vol. 375, no. 9713, pp. 463–474, 2010. View at Publisher · View at Google Scholar · View at Scopus
  87. E. Rivers, B. Nguyen, S. Havstad et al., “Early goal-directed therapy in the treatment of severe sepsis and septic shock,” New England Journal of Medicine, vol. 345, no. 19, pp. 1368–1377, 2001. View at Publisher · View at Google Scholar · View at Scopus
  88. E. P. Rivers, M. Katranji, K. A. Jaehne et al., “Early interventions in severe sepsis and septic shock: a review of the evidence one decade later,” Minerva Anestesiologica, vol. 78, no. 6, pp. 712–724, 2012. View at Google Scholar · View at Scopus
  89. T. R. Craig, M. J. Duffy, M. Shyamsundar et al., “Extravascular lung water indexed to predicted body weight is a novel predictor of intensive care unit mortality in patients with acute lung injury,” Critical Care Medicine, vol. 38, no. 1, pp. 114–120, 2010. View at Publisher · View at Google Scholar · View at Scopus
  90. C. C. Sheu, M. N. Gong, R. Zhai et al., “The influence of infection sites on development and mortality of ARDS,” Intensive Care Medicine, vol. 36, no. 6, pp. 963–970, 2010. View at Publisher · View at Google Scholar · View at Scopus
  91. C. R. Cooke, J. M. Kahn, E. Caldwell et al., “Predictors of hospital mortality in a population-based cohort of patients with acute lung injury,” Critical Care Medicine, vol. 36, no. 5, pp. 1412–1420, 2008. View at Publisher · View at Google Scholar · View at Scopus
  92. L. Papazian, J. M. Forel, A. Gacouin et al., “Neuromuscular blockers in early acute respiratory distress syndrome,” New England Journal of Medicine, vol. 363, no. 12, pp. 1107–1116, 2010. View at Publisher · View at Google Scholar · View at Scopus
  93. A. Afshari, J. Brok, A. M. Møller, and J. Wetterslev, “Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults,” Cochrane Database of Systematic Reviews, vol. 7, Article ID CD002787, 2010. View at Google Scholar · View at Scopus
  94. K. P. Steinberg, L. D. Hudson, R. B. Goodman et al., “Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome,” New England Journal of Medicine, vol. 354, no. 16, pp. 1671–1684, 2006. View at Publisher · View at Google Scholar · View at Scopus
  95. N. Seam, G. U. Meduri, H. Wang et al., “Effects of methylprednisolone infusion on markers of inflammation, coagulation, and angiogenesis in early acute respiratory distress syndrome,” Critical Care Medicine, vol. 40, no. 2, pp. 495–501, 2012. View at Publisher · View at Google Scholar · View at Scopus
  96. M. A. Matthay, R. G. Brower, B. T. Thompson et al., “Randomized, placebo-controlled trial of an aerosolized beta-2 adrenergic agonist (Albuterol) for the treatment of acute lung injury,” American Journal of Respiratory and Critical Care Medicine, vol. 179, Article ID A2166, 2009. View at Google Scholar
  97. T. W. Rice, B. T. Tompson, E. Smoot et al., “Omega-3 (n-3) fatty acid, gamma- linoleic acid (GLA) and anti-oxidant supplementation in acute lung injury (OMEGA trial),” Critical Care Medicine, vol. 37, article A408, 2009. View at Google Scholar
  98. T. W. Rice, A. P. Wheeler, B. T. Thompson et al., “Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial,” Journal of the American Medical Association, vol. 307, no. 8, pp. 795–803, 2012. View at Publisher · View at Google Scholar · View at Scopus