Table 1: Baseline demographic and clinical characteristics.

No antiplatelets
N = 379
Antiplatelets
N = 272
P value

Age, median (IQR)65.8
(53.2 to 78.3)
75.2
(65.2 to 82.5)
<0.001
Female gender, n (%)177 (46.7)112 (41.2)0.16
BMI, Kg/m², median (IQR)27.4
(23 to 32.8)
29
(24.5 to 34.5)
0.015
Caucasian, n (%)340 (89.6)251 (92.3)0.26
Admission source, n (%)
 Emergency department205 (54.1)162 (69.6)0.17
 Medicine wards107 (28.2)69 (25.4)0.42
 Outpatient clinic55 (14.5)28 (10.3)0.11
 Postoperative10 (2.6)7 (2.6)0.96
 Another in-hospital ICU2 (0.53)6 (2.2)0.073
Comorbidities
 Smoking history, n (%) 88 (23.2)70 (25.8)0.46
 Chronic alcohol use, n (%)48 (12.7)17 (6.3)0.0058
 Hypertension, n (%)175 (46.2)200 (73.5)<0.001
 Diabetes mellitus, n (%)113 (29.8)128 (47)<0.001
 Dyslipidemia, n (%)101 (26.7)125 (46)<0.001
 Coronary artery disease, n (%)58 (15.3)152 (55.9)<0.001
 Cerebrovascular disease, n (%)37 (9.8)60 (22)<0.001
 Peripheral artery disease, n (%)34 (9)63 (23.2)<0.001
 Heart failure, n (%)17 (4.5)38 (14)<0.001
 Atrial fibrillation, n (%)62 (16.4)66 (24.3)0.012
 Chronic obstructive pulmonary disease, n (%) 59 (15.6)68 (25)0.0027
 Chronic kidney disease, n (%)65 (17.2)79 (29)<0.001
 Stage V chronic kidney disease, n (%) 30 (7.9)30 (11)0.18
 Active neoplasia, n (%)51 (13.5)37 (13.6)0.96
 Chronic anticoagulation, n (%)66 (17.4)45 (16.5)0.77
 Statin therapy, n (%)78 (20.6)139 (51.1)<0.001
 Pharmacological immunosuppression, n (%) 65 (17.2)38 (14)0.27
 Charlson score, median (IQR)4 (1 to 6)6 (5 to 8)<0.001
Type of antiplatelet, n (%)
 Aspirin241 (88.6)
 Aspirin and clopidogrel27 (9.9)
 Clopidogrel only4 (1.5)
 Aspirin dose, mg, median (IQR)81 (81-81)
Type of infection n (%)
 Community acquired173 (45.6)123 (45.2)0.91
 Health care related/nosocomial206 (54.4)149 (54.8)0.91
Source of infection, n (%)
 Respiratory139 (36.7)82 (30.1)0.083
 Intraabdominal73 (19.3)43 (15.8)0.26
 Urinary60 (15.8)62 (22.8)0.025
 Skin and soft tissue45 (11.9)43 (15.8)0.15
 Line related37 (9.8)15 (5.5)0.002
 Unknown17 (4.5)18 (6.6)0.23
 Other8 (2.1)9 (3.3)0.34
 Positive cultures261 (68.9)182 (66.9)0.6

IQR: interquartile range, n: number, %: percentage, BMI: body mass index, ICU: intensive care unit.