Outcomes of Severe Sepsis and Septic Shock Patients on Chronic Antiplatelet Treatment: A Historical Cohort Study

Table 2

Physiologic scores and laboratory values at the time of ICU admission.

	No antiplatelets; N = 379	Antiplatelets; N = 272	P value
APACHE III 1 hour, median (IQR)	55 (42–68)	57.5 (46–74.8)	0.025
APS 1 hour, median (IQR)	35 (24–49)	36 (25–49.8)	0.64
Predicted hospital death %, median (IQR)	9.2 (4.9–17.4)	10.4 (5.3–21.6)	0.089
SOFA score day 1, median (IQR)	7 (4–10)	6 (4–9)	0.054
ICU admission laboratory results
Hemoglobin, g/dL, median (IQR)	10.9 (9.4–12.5)	11.1 (9.5–12.6)	0.46
Hematocrit %, median (IQR)	32 (27.9–37)	32 (28.3–36.9)	0.45
White blood cells, number * 1000/dL, median (IQR)	12.3 (7.7–18.7)	14.3 (9.4–19.5)	0.017
Platelets, number * 1000/dL, median (IQR)	191 (122–285)	212 (143–307)	0.012
Prothrombin time, sec, median (IQR)	12.8 (10.9–18)	11.9 (10.5–15)	0.01
International normalized ratio, median (IQR)	1.3 (1.1–1.9)	1.2 (1.1–1.6)	0.01
Bicarbonate, mmol/L, median (IQR)	22 (19–25)	22 (18–26)	0.86
Base excess, mmol/L, median (IQR)	4 (8–0)	4 (8–0)	0.76
Lactate, mmol/L, median (IQR)	2.3 (1.3–3.6)	2 (1.3–3.5)	0.56
Baseline creatinine, mg/dL (IQR)	0.9 (0.7–1.1)	1 (0.8–1.5)	<0.001
PaO2/FiO2 ratio, median (IQR)	256 (157–382)	278 (164–381)	0.57

APACHE: Acute Physiologic and Chronic Health Evaluation, IQR: interquartile range, APS: Acute Physiology Score, SOFA: Sequential Organ Failure Assessment, %: percentage, g/dL: grams/deciliter, sec: seconds, mmol/L: millimol/liter, mg/dL: milligrams/deciliter, PaO₂/FiO₂: relation arterial partial pressure of oxygen/fraction of inspired oxygen.