Outcomes of Severe Sepsis and Septic Shock Patients on Chronic Antiplatelet Treatment: A Historical Cohort Study

Table 3

Resuscitation and interventions assessment.

	No antiplatelets; N = 379	Antiplatelets; N = 272	P value
Time to first antibiotic, hours, median (IQR)*	0.25 (−2–1.3)	0.33 (−2.1–1.2)	0.82
Components of resuscitation at 6 hours
MAP, mm Hg, median (IQR)	68 (62–76)	66 (59–76)	0.12
Urine output, mL/Kg/h, median (IQR)	0.54 (0.24–1.18)	0.46 (0.19–1)	0.25
Central venous pressure, median (IQR)
Patients on MV	12 (9–16)	12 (7–16)	0.69
Patients without MV	8 (5–13)	8 (5–12)	0.92
ScVO2, %, median, (IQR)	74 (67–78)	71 (64–76)	0.02
Transfusion therapy during ICU hospitalization
Blood product transfusion, number of patients (%)	187 (49.3)	127 (46.7)	0.50
Red blood cells transfusion, number of patients (%)	161 (42.5)	114 (41.9)	0.89
Red blood cells units transfused, number, median (IQR)	2 (2–4)	2 (2-3)	0.27
Platelets transfusion, number of patients (%)	41 (10.8)	14 (5.1)	0.01
Platelet units transfused, number, median (IQR)	2 (1–5.5)	2 (1–3.3)	0.58
Fresh frozen plasma transfusion, number of patients (%)	64 (16.9)	38 (14)	0.31
Fresh frozen plasma units transfused, number, median (IQR)	2 (2–6)	2.5 (2–4)	0.14
Cryoprecipitates transfusion, number of patients (%)	10 (2.6)	8 (2.9)	0.82
Cryoprecipitates units transfused, number, median (IQR)	4 (2–6)	2 (2–3.5)	0.14
Adjuvant therapy
Stress dose steroids, n (%)	143 (37.3)	86 (31.6)	0.11
Drotrecogin alfa activated, n (%)	7 (1.9)	0	0.046
Vasopressors, n (%)	231 (61)	149 (54.8)	0.12
Length of vasopressors, hours, median (IQR)	33 (12–75)	28 (13–54.5)	0.29

IQR: interquartile range, MAP: mean arterial pressure, mm Hg: millimeters of mercury, mL/Kg/h: milliliters/kilogram/hour, ScVO₂: central venous oxygen saturation, %: percentage, n: number, ICU: intensive care unit.
*Time from first antibiotic to severe sepsis or septic shock diagnosis.