Table 3: Resuscitation and interventions assessment.

No antiplatelets
N = 379
Antiplatelets
N = 272
P value

Time to first antibiotic, hours, median (IQR)*0.25 (−2–1.3)0.33 (−2.1–1.2)0.82
Components of resuscitation at 6 hours
 MAP, mm Hg, median (IQR)68 (62–76)66 (59–76)0.12
 Urine output, mL/Kg/h, median (IQR)0.54 (0.24–1.18)0.46 (0.19–1)0.25
 Central venous pressure, median (IQR)
Patients on MV12 (9–16)12 (7–16)0.69
Patients without MV8 (5–13)8 (5–12)0.92
  ScVO2, %, median, (IQR)74 (67–78)71 (64–76)0.02
Transfusion therapy during ICU hospitalization
 Blood product transfusion, number of patients (%)187 (49.3)127 (46.7)0.50
 Red blood cells transfusion, number of patients (%)161 (42.5)114 (41.9)0.89
 Red blood cells units transfused, number, median (IQR)2 (2–4)2 (2-3)0.27
 Platelets transfusion, number of patients (%)41 (10.8)14 (5.1)0.01
 Platelet units transfused, number, median (IQR)2 (1–5.5)2 (1–3.3)0.58
 Fresh frozen plasma transfusion, number of patients (%)64 (16.9)38 (14)0.31
 Fresh frozen plasma units transfused, number, median (IQR)2 (2–6)2.5 (2–4)0.14
 Cryoprecipitates transfusion, number of patients (%)10 (2.6)8 (2.9)0.82
 Cryoprecipitates units transfused, number, median (IQR)4 (2–6)2 (2–3.5)0.14
Adjuvant therapy
 Stress dose steroids, n (%)143 (37.3)86 (31.6)0.11
 Drotrecogin alfa activated, n (%)7 (1.9)00.046
 Vasopressors, n (%)231 (61)149 (54.8)0.12
 Length of vasopressors, hours, median (IQR)33 (12–75)28 (13–54.5)0.29

IQR: interquartile range, MAP: mean arterial pressure, mm Hg: millimeters of mercury, mL/Kg/h: milliliters/kilogram/hour, ScVO2: central venous oxygen saturation, %: percentage, n: number, ICU: intensive care unit.
*Time from first antibiotic to severe sepsis or septic shock diagnosis.