An Observational Study on Early Empiric versus Culture-Directed Antifungal Therapy in Critically Ill with Intra-Abdominal Sepsis

Table 3

Microbiological results.

	Empiric (𝑛=30)	Culture-directed (𝑛=18)	𝑃 value
Number of subjects with positive fungal cultures, 𝑛 (%)	16 (53)	18 (100)	0.003
Number of subjects with significant fungal cultures, 𝑛 (%)	12 (40)	14 (78)	0.011
Presence of concomitant bacterial infection, 𝑛 (%)	28 (93)	15 (83)	0.349
Types of Candida species, 𝑛 (%)
C. spp.	10 (33)	14 (78)	0.003
C. albicans	7 (23)	8 (44)	0.127
C. tropicalis	3 (10)	4 (22)	0.400
C. glabrata	4 (13)	2 (11)	1.000
C. krusei	1 (3)	1 (6)	1.000
C. parapsilosis	1 (3)	0	1.000
C. dubliniensis	1 (3)	0	1.000
Location of isolated Candida, 𝑛 (%)
Sputum	5 (17)	3 (17)	1.000
Central venous catheter	0	1 (6)	0.375
Urine	8 (27)	7 (39)	0.376
Blood	3 (10)	4 (22)	0.400
Abdominal wound	3 (10)	5 (28)	0.132
Intraoperative wound	0	5 (28)	0.005
Peritoneal fluid	6 (20)	10 (56)	0.011
Drain	2 (7)	2 (11)	0.624