Dose-Dependent Hemodynamic, Biochemical, and Tissue Oxygen Effects of OC99 following Severe Oxygen Debt Produced by Hemorrhagic Shock in Dogs
Table 4
Means (with standard errors) for the plasma colloid-osmotic-pressure (COP) as well as the systemic (SVR) and pulmonary (PVR) vascular resistances as measured/estimated at baseline (Base) and at the end of treatment (End-dose).
Parameter (units)/group
Baseline
End-dose
%Change
COP (mmHg)
HEX + CTRL
16.5 (0.5)
14.6 (0.4)
−11.1 (2.2)
HEX + LOW
16.3 (0.9)
14.6 (0.6)
−9.6 (4.5)
HEX + MID
16.4 (1.1)
16.6 (1.1)
1.7 (5.4)
HEX + HIGH
15.7 (0.9)
17.4 (0.7)
11.2 (3.3)
SVR (dyne/cm/s−5)
HEX + CTRL
4,560 (171)
3,743 (236)
−17.9 (4.6)
HEX + LOW
4,201 (378)
3,975 (417)
−3.3 (8.9)
HEX + MID
4,160 (110)
4,415 (270)
6.3 (6.6)
HEX + HIGH
3,845 (187)
4,293 (205)
13.4 (8.8)*
PVR (dyne/cm/s−5)
HEX + CTRL
485 (51)
647 (75)
35.0 (9.5)
HEX + LOW
507 (47)
734 (83)
45.3 (12.6)
HEX + MID
440 (9)
676 (62)
53.4 (13.5)
HEX + HIGH
452 (17)
881 (70)*
96.2 (16.2)*
Data are mean values (standard error of the mean). (adjusted) versus HEX + LRS.
