Dose-Dependent Hemodynamic, Biochemical, and Tissue Oxygen Effects of OC99 following Severe Oxygen Debt Produced by Hemorrhagic Shock in Dogs

Table 5

Indices indicative of both hemodynamic (systolic blood pressure, SBP) and oxygenation (tissue oxygen tension, TO₂) recovery¹ following the administration of either the placebo (LRS) or the test article (OC99): time to recovery (TtR) and duration of recovery (DoR).

Group^†,‡	tPO2 (>10 mmHg)			SBP (>90 mmHg)
	TtR (min)	DoR (min)	%^2	TtR (min)	DoR (min)	%^2
HEX + CTRL	50.0 (19.1)	56.7 (27.0)	2/6	26.7 (4.2)	136.7 (15.8)	2/6
HEX + LOW	35.0 (9.6)	76.7 (26.0)	4/6	23.3 (3.3)	150.0 (13.4)	6/6
HEX + MID	33.3 (6.7)	150.0 (19.1)*	6/6	20.0 (0.0)	170.0 (10.0)	6/6
HEX + HIGH	23.3 (3.3)	176.7 (3.3)*	6/6	20.0 (0.0)	180.0 (0.0)*	6/6
-value	0.8415	0.0005		0.4402	0.0178

Data are mean values (standard error of the mean).
For the purposes of this study, “oxygenation” and “hemodynamic” recovery were defined as the time point(s) when the tissue (intestinal) oxygen tension (TO₂) and the systemic (systolic) blood pressure (SBP) (resp.) reached values associated with sustainable normal physiological function (TO₂ > 10 mmHg, SBP > 90 mmHg).
The ratio of the number of animals that reached the set threshold level. For the TO₂ parameter, there were 2 animals from the HEX + LRS group and 2 animals from the HEX + LOW group that did not reach the set threshold level.
Treatments delivered via continuous IV infusion over 60 min at 10 mL/kg/hr (combined) in the setting of fluid-resuscitation (20 mL/kg at 20 mL/kg/hr) with either Hextend (HEX+) or LRS (LRS+); end of dosing (DOSE_END) is time zero (t = 0 hr), while END is the mean value readings taken 2 hours after dosing (140, 160, and 180 min).
LRS (): 10 mL/kg of LRS; LOW (): 1 mL/kg of OC99 + 9 mL/kg of LRS; MID (): 5 mL/kg of OC99 + 5 mL/kg of LRS; HIGH (): 10 mL/kg of OC99.
(adjusted) versus HEX + LRS.