Resurgence of Polymyxin B for MDR/XDR Gram-Negative Infections: An Overview of Current Evidence

Table 2

Population pharmacokinetics of polymyxin B [26].

Parameter	Observation (range)
(mg hour/L)	66.9 ± 21.6 (16.4–117)
(mg hour/L)	29.2 ± 12.0 (6.05–60.5)
(mg/L)	2.79 ± 0.90 (0.68–4.88)
Renal Clearance (L/hour)	0.061 (0.018–0.377)
Urinary excretion (%)	4.04 (0.98–17.4)

: AUC over a day; : average steady-state plasma concentration; : AUC for unbound fraction.