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Critical Care Research and Practice
Volume 2017, Article ID 5804860, 5 pages
https://doi.org/10.1155/2017/5804860
Research Article

A Retrospective, Pilot Study of De Novo Antidepressant Medication Initiation in Intensive Care Unit Patients and Post-ICU Depression

1Department of Anesthesiology, University of Kansas Hospital, Kansas City, KS, USA
2Department of Biostatistics, University of Kansas Hospital, Kansas City, KS, USA
3Department of Pharmacy, University of Kansas Hospital, Kansas City, KS, USA
4Department of Surgery, University of Kansas Hospital, Kansas City, KS, USA
5Department of Medicine, University of Kansas Hospital, Kansas City, KS, USA

Correspondence should be addressed to Brigid C. Flynn; ude.cmuk@nnylfb

Received 16 May 2017; Revised 13 July 2017; Accepted 6 August 2017; Published 13 September 2017

Academic Editor: Loek Leenen

Copyright © 2017 Daniel Haines et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Post-ICU Syndromes (PICS) remain a devastating problem for intensive care unit (ICU) survivors. It is currently unknown if de novo initiation of an antidepressant medication during ICU stay decreases the prevalence of post-ICU depression. We performed a retrospective, pilot study evaluating patients who had not previously been on an antidepressant medication and who were started on an antidepressant while in the trauma surgical, cardiothoracic, or medical intensive care unit (ICU). The PHQ-2 depression scale was used to ascertain the presence of depression after ICU discharge and compared this to historical controls. Of 2,988 patients admitted to the ICU, 69 patients had de novo initiation of an antidepressant medication and 27 patients were alive and available for study inclusion. We found the prevalence of depression in these patients to be 26%, which is not statistically different than the prevalence of post-ICU depression in historical controls [95% CI (27.6%, 51.6%)]. De novo initiation of an antidepressant medication did not substantially decrease the prevalence of post-ICU depression in this retrospective, pilot study.