Reversal Strategies for Intracranial Hemorrhage Related to Direct Oral Anticoagulant Medications

Figure 2

Management algorithm for DOAC-related hemorrhage [13, 14, 28, 35, 38, 44]. ABC = airway, breathing, circulation, aPCC = activated prothrombin complex concentrate, BMP = basic metabolic panel, BP = blood pressure, CBC = complete blood count, CT = computerized tomography, DOACs = direct oral anticoagulants, ED = emergency department, EVD = external ventricular drain, GCS = Glasgow Coma Scale, GI = gastrointestinal, i.v. = intravenous, ICH = intracranial hemorrhage, ICP = intracranial pressure, ICU = intensive care unit, INR = international normalized ratio, IVH = intraventricular hemorrhage, kg = kilogram, mg = milligram, NVAF = nonvalvular atrial fibrillation, PaO₂ = partial pressure of oxygen, PCC = prothrombin complex concentrate, PTT = partial thromboplastin time, SaO₂ = oxygen saturation, SBP = systolic blood pressure, SC = subcutaneous, SCD = sequential compression device, and VTE = venous thromboembolism.