Emerging Evidence concerning the Role of Sirtuins in Sepsis

Table 2

Relationship between SIRT1 inhibition and sepsis-induced cell damage.

Sepsis model	Main treatment	Effects	Reference
Human monocyte cell model of endotoxin tolerance and human leukocytes from sepsis	SIRT1 inhibition	Increased TNF-α expression and promotes the inflammatory response	[33]
TLR4-stimulated THP-1 promonocytes, blood leukocytes from septic human, and plenocytes from septic mice	SIRT1 inhibition	Decreased fatty acid oxidation	[34]
Septic mice	SIRT1 inhibition	Restored repressed endothelial E-selectin and ICAM-1 expression and PSGL-1 expression on neutrophils	[35]
LPS-stimulated J774 macrophages	SIRT1 inhibition	Reduced cytokine production and decreased NF-κB activity	[36]
CLP rats	SIRT1 inhibition	Attenuates cytokine levels, induces coagulopathy, and decreases bone marrow atrophy	[37]