Anemia, Blood Transfusion, and Filter Life Span in Critically Ill Patients Requiring Continuous Renal Replacement Therapy for Acute Kidney Injury: A Case-Control Study
Table 2
Characteristics of patients on continuous renal replacement therapy for acute kidney injury categorized according to the median of the filter life span (20 hours).
Filter life span <20 hours (N = 44)
Filter life span ≥20 hours (N = 51)
value
Age (years), mean ± SD
58.1 ± 16.3
60.5 ± 14.1
0.45
Male gender, N (%)
25 (56.8)
34 (66.7)
0.32
Body mass index (kg/m2), mean ± SD
38.1 ± 38.4
29.9 ± 7.5
0.14
APACHE II score, mean ± SD
26.2 ± 7.1
25.8 ± 7.1
0.79
Admission type, N (%)
0.17
Medical
43 (97.7)
46 (90.2)
Surgical
0 (0)
4 (7.8)
Trauma
1 (2.3)
1 (2.0)
Chronic illnesses, N (%)
Cardiac comorbidity
24 (54.5)
22 (43.1)
0.27
Respiratory comorbidity
9 (20.5)
11 (21.6)
0.89
Hepatic comorbidity
3 (6.8)
6 (11.8)
0.50
Renal comorbidity
12 (27.3)
16 (31.4)
0.66
Immunocompromised state
4 (9.1)
4 (7.8)
0.56
Diabetes
29 (65.9)
31 (60.8)
0.61
Hypertension
28 (63.6)
33 (64.)
0.91
Sepsis on admission, N (%)
12 (27.3)
22 (43.1)
0.11
Shock on admission, N (%)
10 (22.7)
17 (33.3)
0.25
Requirement for mechanical ventilation, N (%)
40 (90.9)
49 (96.1)
0.30
Prefilter heparin use, N (%)
17 (38.6%)
15 (29.4%)
0.34
Location of hemodialysis access
0.98
Femoral vein
26 (59.1%)
31 (60.8%)
Internal jugular vein
17 (38.6%)
19 (37.3%)
Other
1 (2.3)
1 (2.0)
Laboratory findings
Serum creatinine on admission (micromol/L), mean ± SD
263.2 ± 228.3
286.1 ± 243.6
0.32
Serum creatinine on CRRT start (micromol/L), mean ± SD
366.0 ± 228.3
286.1 ± 169.0
0.06
Serum creatinine highest (micromol/L), mean ± SD
469.0 ± 243.6
367.6 ± 183.6
0.23
Albumin on admission (g/L), mean ± SD
29.4 ± 5.4
28.5 ± 5.3
0.42
Lactate on admission (mmol/L), mean ± SD
3.2 ± 4.1
3.4 ± 2.8
0.78
Platelet count on admission (×109/L), mean ± SD
206.9 ± 105.5
192.5 ± 128.6
0.56
Hemoglobin on admission (g/L), mean ± SD
113. 9 ± 19.1
110.31 ± 18.5
0.36
Highest INR during CRRT, mean ± SD
2.2 ± 1.6
2.3 ± 1.5
0.73
Highest aPTT during CRRT (seconds), mean ± SD
83.2 ± 56.6
84.6 ± 46.6
0.89
Lowest platelet during CRRT (×109/L), mean ± SD
95.8 ± 84.5
83.4 ± 71.6
0.45
Number of PRBC units transfused during CRRT, mean ± SD
2.5 ± 4.3
2.7 ± 3.8
0.81
Number of platelet units transfused during CRRT, mean ± SD
6.0 ± 13.3
63 ± 12.7
0.90
Number of FFP units transfused during CRRT, mean ± SD
3.1 ± 6.3
5.4 ± 11.3
0.24
APACHE: Acute Physiology and Chronic Health Evaluation; aPTT: activated partial thromboplastin time; CRRT: continuous renal replacement therapy; FFP: fresh frozen plasma; INR: international normalized ratio; PRBC: packed red blood cell; SD: standard deviation.
