Intravenous Fluid of Choice in Major Abdominal Surgery: A Systematic Review

Table 10

Overview of randomized control trials related to PONV by primary outcome.

Author, year	Fluid compared	N	Operation	Conclusion
Primary outcome: PONV
Chaudhary [19], 2008	LRS 2 mL/kg; LRS 12 mL/kg; 4.5% hetastarch 12 mL/kg	60	Open cholecystectomy	Preoperative fluid supplement rate (12 mL/kg) (both colloid and crystalloid) decreases incidence of PONV, vomiting, and use of antiemetic
Mishra [36], 2017	NSS; 5% dextrose	100	Laparoscopic cholecystectomy	5% dextrose fluid reduced incidence of PONV, but not vomiting
Rao [42], 2017	LRS; 5% dextrose	112	Laparoscopic cholecystectomy	Postoperative IV loading 1000 mL of 5% dextrose fluid reduced incidence of PONV, but not vomiting
Primary outcome was another objective but also had these outcome
Ghodraty [22], 2017	6% HES130/0.4 (Voluven); LRS	91	GI surgery	HES 130/0.4 reduced incidence of vomiting, but not PONV

PONV = postoperative nausea vomiting, HES = hydroxyethyl starch, NSS = normal saline solution, LRS = lactated Ringer’s solution, and GI = gastrointestinal.